Evidence map›Paper›PMID 40858902›Full record

Trial reportScientific reports2025

An experimental study on the effect of symptom expectations on mental fatigue and motivation in people with primary biliary cholangitis.

Laura Buck, Jule Herzberg, Bert Lenaert, Bernd Löwe, Johannes Hartl, Christoph Schramm, Anne Toussaint

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura BuckDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. l.buck@uke.de.
Jule HerzbergDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bert LenaertDepartment of Life Span Psychology, Faculty of Psychology, Open University, Heerlen, The Netherlands.
Bernd LöweDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Johannes HartlI. Department of Medicine, University Medical Center Hamburg- Eppendorf, Hamburg, Germany.
Christoph SchrammI. Department of Medicine, University Medical Center Hamburg- Eppendorf, Hamburg, Germany.
Anne ToussaintDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatigue is the most common symptom in people with primary biliary cholangitis (PBC) and resistant to current treatment modalities. The aim of this study was to investigate the effect of negative and positive fatigue expectations in people with PBC on experienced fatigue and the motivational urge to stop a cognitive task. A subsample of the SOMA.LIV study of N = 46 people with PBC was randomly assigned to two experimental conditions. They received either fatigue-inducing or fatigue-reducing task instructions for a subsequent cognitive task. Participants rated their fatigue expectations prior to the task and their fatigue and motivational urge to stop after each of five task blocks. The total sample showed an increase in subjective fatigue and urge to stop across all task blocks. Participants receiving fatigue-inducing task instructions reported higher urge to stop compared to the group with fatigue-reducing task instructions. Both groups did not differ significantly in fatigue expectations and subjective fatigue. Our findings suggest that people with PBC may benefit from encouragement to engage in cognitive activities and maintain mental effort by verbal suggestions - an effect that can be of use in clinical practice to reduce potential avoidance behaviour.

Indexed as

Liver Cirrhosis, BiliaryMental FatigueMotivationAdultAgedCognitionFatigueFemaleHumansMaleMiddle AgedAutoimmune liver diseaseFatigueMotivationSymptom expectationsWorking memory

Identifiers

PMID40858902
PMCPMC12381113

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.