Evidence map›Paper›PMID 40859042›Full record

ArticleUpdates in surgery2025

Liver hypertrophy techniques: a position paper from the Italian Group of Regenerative and Occlusive Worldwide-used techniques of hepatic Hypertrophy (I GROWtoH).

Matteo Serenari, Francesca Ratti, Mohammed Abu Hilal, Francesco Ardito, Giammauro Berardi, Ugo Boggi, Alberta Cappelli, Matteo Cescon, Umberto Cillo, Alessandro Cucchetti and 36 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Advanced robotic liver surgery.Surgical endoscopy · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Matteo Serenari *Hepato-Biliary Surgery and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, 40138, Bologna, Italy. matteo.serenari@gmail.com.ORCID http://orcid.org/0000-0003-1471-8585
Francesca Ratti *Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Mohammed Abu HilalDepartment of HPB Surgery, University Hospital Southampton, Southampton, UK.
Francesco ArditoHepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy.
Giammauro BerardiDepartment of Surgery, San Camillo Forlanini Hospital, Rome, Italy.
Ugo BoggiDepartment of Surgery, University Hospital of Pisa, Pisa, Italy.
Alberta CappelliDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Matteo CesconHepato-Biliary Surgery and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, 40138, Bologna, Italy.
Umberto CilloGeneral Surgery 2-Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, Padua, Italy.
Alessandro CucchettiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Luciano De CarlisDepartment of General Surgery and Transplantation, School of Medicine, Niguarda Hospital-University of Milano-Bicocca, Milan, Italy.
Francesco De CobelliVita-Salute San Raffaele University, Milan, Italy.
Fabrizio Di BenedettoHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Giorgio ErcolaniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Giuseppe Maria EttorreDepartment of Surgery, San Camillo Forlanini Hospital, Rome, Italy.
Massimo FediHepatobiliary Surgery Unit, USL Toscana Centro-San Jacopo Hospital, Pistoia, Italy.
Alessandro FerreroDepartment of Surgery, Mauriziano Hospital, Turin, Italy.
Felice GiulianteHepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy.
Gian Luca GraziHepatobiliaryPancreatic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Enrico GringeriGeneral Surgery 2-Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, Padua, Italy.
Salvatore GruttadauriaDepartment Abdominal Center, UPMC (University of Pittsburgh Medical Center), 90127, Palermo, Italy.
Francesco IzzoDivision of Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", Napoli, Italy.
Marcello MaestriDivision of General Surgery 1, Department of Surgery, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Paolo MagistriHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Marco MassaniRegional Center for HPB Surgery, Regional Hospital of Treviso, Treviso, Italy.
Vincenzo MazzaferroDepartment of Surgery, Division of HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, Milan, Italy.
Riccardo MemeoDivision of Hepato-Pancreato-Biliary Surgery, "F. Miulli" General Hospital, Acquaviva Delle Fonti, Bari, Italy.
Federico MocchegianiHPB Surgery and Transplantation Unit, Department of Clinical and Experimental Medicine, Polytechnic University of Marche, Ancona, Italy.
Cristina MosconiDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Damiano PatronoGeneral Surgery 2U-Liver Transplant Unit, Department of Surgical Sciences, Azienda Ospedaliero Universitaria Città Della Salute E Della Scienza Di Torino, Università Di Torino, Turin, Italy.
Matteo RavaioliHepato-Biliary Surgery and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Albertoni 15, 40138, Bologna, Italy.
Fabrizio RomanoSchool of Medicine and Surgery, Hepatobiliary Surgery, University of Milan Bicocca, IRCCS San Gerardo, Monza, Italy.
Gianluca RompianesiDivision of HPB, Minimally Invasive and Robotic Surgery, Transplantation Service, Federico II University Hospital, Naples, Italy.
Nadia RussolilloDepartment of Surgery, Mauriziano Hospital, Turin, Italy.
Andrea RuzzenenteDivision of General and Hepatobiliary Surgery, G.B, University of Verona, Rossi University Hospital, Verona, Italy.
Carlo SpositoDepartment of Surgery, Division of HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, Milan, Italy.
Roberto TroisiDivision of HPB, Minimally Invasive and Robotic Surgery, Transplantation Service, Federico II University Hospital, Naples, Italy.
Giovanni VennarecciDepartment of Hepatobiliary and Liver Transplantation Surgery, A.O.R.N. Cardarelli, Naples, Italy.
Luca ViganòDepartment of Minimally Invasive General & Oncologic Surgery, Hepatobiliary Unit, Humanitas Gavazzeni University Hospital, Bergamo, Italy.
Marco VivarelliDivision of Hepato-Pancreato-Biliary Surgery, "F. Miulli" General Hospital, Acquaviva Delle Fonti, Bari, Italy.
Giacomo ZanusDepartment of Surgical, Oncological and Gastroenterological Science (DISCOG), University of Padua, Padua, Italy.
Pedro M BaptistaLaboratory of Organ Bioengineering and Regenerative Medicine, Health Research Institute of Aragon (IIS Aragon), Saragossa, Spain.
Karl OldhaferDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Asklepios Hospital Barmbek, Hamburg, Germany.
Erik SchaddeDepartment of Surgery, Rush University Chicago, Chicago, IL, USA.
Luca Aldrighetti *Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Elio Jovine *Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In candidates for hepatectomy, different techniques to induce liver hypertrophy and modulate the future liver remnant are available. However, their use in specific clinical scenarios is highly heterogeneous and there is no consensus about minimal safety standards needed to incorporate these strategies into routine clinical practice. The aim of this position paper was to summarize newly available evidence in the field and compare medical practice among different hepatobiliary surgical units to evaluate the transformative potential of liver hypertrophy techniques in surgical oncology. This paper sets the stage for a future structured consensus on the application of liver hypertrophy techniques before hepatectomy.

Indexed as

HepatectomyLiverLiver RegenerationHumansHypertrophyItalyLiver NeoplasmsLiver functionLiver hypertrophyLiver volumePortal vein embolization

Identifiers

PMID40859042
PMCPMC12630264

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.