Evidence map›Paper›PMID 40859372›Full record

ArticleTrials2025

The effects of remimazolam on the incidence of severe hypoxemia during sedated hysteroscopy for assisted reproduction in overweight or obese patients: a randomized controlled clinical trial.

Yanhua He, Jie Zhou, Xibing Ding, Xiaorong Huai, Shujing Lin, Weifeng Yu, Diansan Su

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06187896 (The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06187896 narecruitingnot on this map

The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients: a Randomized, Controlled Clinical Trial

TypeinterventionalSponsorRenJi HospitalRan2024 to 2026Enrolled600ConditionsHypoxia, Hysteroscopy, Overweight or ObesityArmsremimazolam, Propofol
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanhua He *Department of Anesthesiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Jie Zhou *Department of Anesthesiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Xibing DingDepartment of Anesthesiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Xiaorong HuaiDepartment of Anesthesiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Shujing LinDepartment of Anesthesiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Weifeng YuDepartment of Anesthesiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Diansan SuDepartment of Anesthesiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China. diansansu@yahoo.com.ORCID http://orcid.org/0000-0001-9755-1025

Funding

Shanghai Municipal Health Commission 202340088
6 · The paper itself

Abstract

backgroundHypoxemia is the most common adverse reaction during sedated hysteroscopy. Obesity is a risk factor for hypoxemia. For hysteroscopy, propofol is the most commonly used sedative. However, it can cause dose-dependent respiratory depression. This drawback has driven the search for sedatives with less respiratory depressant effects. Remimazolam is a new benzodiazepine drug with several advantages, including minimal impact on the respiratory and circulatory systems. This study aims to compare remimazolam and propofol in terms of safety and efficacy in patients with overweight or obesity who are undergoing sedated hysteroscopy.

methodsThis prospective, single-center, randomized, single-blind, controlled clinical trial will be conducted to examine the effect of remimazolam on the incidence of severe hypoxemia in patients with overweight or obesity. Patients (n = 600) scheduled to undergo sedated hysteroscopy will be randomly assigned to either the control or experimental group and will be sedated using propofol or remimazolam, respectively. DISCUSSION: The main objective of this study is to determine whether remimazolam can reduce the incidence of severe hypoxemia in patients with overweight or obesity during hysteroscopy. The results of this study are expected to provide evidence on the safety and efficacy of remimazolam in patients with overweight or obesity, which will enhance patient comfort and safety during sedated hysteroscopy.

trial registrationClinicalTrials.gov NCT06187896. Registered on January 3, 2024.

Indexed as

BenzodiazepinesHypnotics and SedativesHypoxiaHysteroscopyObesityOverweightReproductive Techniques, AssistedAdultFemaleHumansIncidenceMiddle AgedPropofolProspective StudiesRandomized Controlled Trials as TopicSingle-Blind MethodBenzodiazepinesHypnotics and SedativesPropofolremimazolamHypoxemiaPropofolRemimazolamSedated hysteroscopy

Identifiers

PMID40859372
PMCPMC12379506

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.