Evidence map›Paper›PMID 40859609›Full record

ArticlePhysiological reports2025

The air pollutant phenanthrene disrupts calcium cycling and alters repolarization in female sheep ventricular cardiomyocytes.

C R Marris, S N Kompella, A W Trafford, J C Hancox, H A Shiels

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

C R MarrisDivision of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0001-7555-4452
S N KompellaDivision of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0001-5625-2491
A W TraffordDivision of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0002-2770-445X
J C HancoxCardiovascular Research Laboratories, Biomedical Sciences Building, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-2055-6482
H A ShielsDivision of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0001-5223-5205

Funding

British Heart Foundation (BHF) PG/17/77/33125
6 · The paper itself

Abstract

Multiple epidemiological studies link cardiac dysfunction with increased levels of air pollution. While cellular mechanisms underlying such dysfunction are yet to be fully elucidated, a proposed mediator of this effect is phenanthrene, a 3-ringed polycyclic aromatic hydrocarbon (PAH). Here, we used ventricular myocytes freshly isolated from healthy female sheep (Ovis aries) to study the impact of acute phenanthrene exposure on cardiac electrophysiology and intracellular Ca

Indexed as

Action PotentialsAir PollutantsCalciumCalcium SignalingMyocytes, CardiacPhenanthrenesAnimalsFemaleHeart VentriclesSheepAir PollutantsCalciumphenanthrenePhenanthrenesaction potentialCa2+ transientIKlarge animal modelovinetricyclic polyaromatic hydrocarbons

Identifiers

PMID40859609
PMCPMC12380724

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.