ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Factors associated with age at tau pathology onset and time from tau onset to dementia in Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Do amyloid trajectories reach a ceiling? Evidence from iterative approximation and simulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Classification of tau status with machine learning models in amyloid-positive cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A critical appraisal of the link between apolipoprotein E and Tau.Current opinion in neurology · 2026Review
- Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks.Nature medicine · 2026Article
- Article
- Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort.JAMA network open · 2026Article
- Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments.NPJ dementia · 2026Review
- Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease using PET and Plasma Biomarkers.medRxiv : the preprint server for health sciences · 2025Article
- Factors associated with age at tau pathology onset and time from tau onset to dementia in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Tau biology, biomarkers, and therapeutics.Alzheimer's & dementia (New York, N. Y.)Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
introductionElevated tau (T+) is temporally proximal to dementia onset but less is known about factors influencing T+ onset age and time to dementia after T+ in Alzheimer's disease (AD). We used sampled iterative local approximation (SILA) estimated T+ onset age (ETOA) to investigate factors associated with T+ age and time from T+ to dementia onset in the Alzheimer's Disease Neuroimaging Initiative.
methodsUsing SILA-estimated amyloid positivity and T+ onset ages derived from
resultsHigher amyloid, APOE-ε4, lower education, and lower literacy associated with younger ETOA. Older ETOA and higher amyloid associated with shorter time from T+ to dementia. DISCUSSION: This work highlights the prognostic value of ETOA and the need to better characterize factors contributing to ETOA and dementia onset in AD. HIGHLIGHTS: We applied sampled iterative local approximation (SILA) to Alzheimer's Disease Neuroimaging Initiative
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.