Evidence map›Paper›PMID 40859796›Full record

ArticleCancer science2025

Tumor Endothelial Cells Induce M2 Macrophage Polarization via IL-4, Enhancing Tumor Growth in Hepatocellular Carcinoma.

Daijiro Matoba, Takehiro Noda, Shogo Kobayashi, Yoshihiro Sakano, Kenichi Matsumoto, Chihiro Yamanaka, Kazuki Sasaki, Shinichiro Hasegawa, Yoshifumi Iwagami, Daisaku Yamada and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Daijiro MatobaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Takehiro NodaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0002-6768-5783
Shogo KobayashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0002-8828-1067
Yoshihiro SakanoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0002-7633-6657
Kenichi MatsumotoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Chihiro YamanakaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Kazuki SasakiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Shinichiro HasegawaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Yoshifumi IwagamiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Daisaku YamadaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0002-6702-3800
Yoshito TomimaruDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0002-4432-060X
Hirofumi AkitaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Hidenori TakahashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0003-4801-3540
Tadafumi AsaokaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Junzo ShimizuDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Hisashi WadaDepartment of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0002-2318-1129

Funding

Japan Society for the Promotion of Science (C) 22K08870Japan Society for the Promotion of Science (C) 22K16530
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) and tumor endothelial cells (TECs) are important components in tumor microenvironments. This study examined the interaction between TECs and TAMs in hepatocellular carcinoma (HCC). The aim of this study is to clarify the mechanism of immune suppression and cancer progression mediated by the M2 polarization of TAMs. TECs were isolated from subcutaneous HCC tumors using murine BNL-T cells, and normal endothelial cells (NECs) were isolated from murine liver. M0 macrophages were obtained from bone marrow after incubation with M-CSF. Conditioned medium from TECs (TEC CM) or NECs (NEC CM) was added to M0 macrophages, and the polarization to M2 macrophages was assessed. The percentage of iNOS

Indexed as

Carcinoma, HepatocellularEndothelial CellsInterleukin-4Liver NeoplasmsMacrophagesTumor-Associated MacrophagesAnimalsCell Line, TumorCell PolarityCulture Media, ConditionedFemaleHumansMaleMiceReceptors, Cell SurfaceTumor MicroenvironmentCulture Media, ConditionedInterleukin-4Receptors, Cell Surfaceimmune suppressiontumor‐associated macrophagetumor‐endothelial cellstumor microenvironmenttumor vessel

Identifiers

PMID40859796
PMCPMC12580878

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.