ArticleJournal of conservative dentistry and endodontics2025
Effect of biodentine modified with bioactive glass nanoparticles on biocompatibility, osteogenic differentiation, and gene expression of human dental pulp stem cells.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of chitosan and bioactive glass nanoparticles on pulp-dentin regeneration: a systematic review ofFrontiers in dental medicine · 2026Pooled it
- Exosome-loaded human amniotic membrane hydrogel modulates regenerative responses of human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2026Article
- Cytocompatibility of calcium hydroxide medicament combined with cationic peptide - AnJournal of conservative dentistry and endodontics · 2026Article
- Modifications of Biodentine and Their Influence on Endodontic Properties: A Scoping Review.International journal of dentistry · 2026Review
- Wharton's jelly mesenchymal stem cell-derived exosomes promote odontogenic differentiation of dental pulp stem cells: A cell-free strategy for regenerative endodontics.Journal of conservative dentistry and endodontics · 2026Article
- Repair of critical bone defects with two bioceramics in rat calvaria.Journal of conservative dentistry and endodontics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Achieving a proper root-end seal is essential for the success of endodontic surgery, ensuring prevention of microleakage, promoting healing, and enhancing treatment longevity. Aim: The study aimed to evaluate and compare the biocompatibility, osteogenic differentiation, and gene expression of mineral trioxide aggregate (MTA), biodentine (BD), and BD modified with bioactive glass nanoparticles (nBAG) on human dental pulp stem cells. Materials and Methods: Discs were prepared using unmodified Biodentine (BD), BD combined with 1%, 3%, and 5% (w/w) Bioactive glass nanoparticles (nBAG), with MTA serving as the control group. Biocompatibility and cell morphology were assessed using the MTT assay. Osteogenic potential was evaluated through alizarin red S staining, and gene expression of alkaline phosphatase (ALP) and osteonectin (OSN) was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). Results: All groups were biocompatible, though BD + 3% nBAG showed slightly reduced cell viability. Alizarin red S staining demonstrated significantly higher mineral deposition in BD + nBAG groups versus BD and MTA. However, qRT-PCR indicated that MTA had the highest ALP and OSN expression, while BD and BD + 3% nBAG showed reduced gene expression. Conclusion: Incorporation of nBAG into BD improved mineralization while maintaining cytocompatibility. However, decreased osteogenic gene expression highlights the need for further formulation refinement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.