Evidence map›Paper›PMID 40860441›Full record

ArticleiMeta2025

Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end-stage renal disease.

Xiaoxue Liu, Yuan Huang, Yixuan Li, Juan Chen, Xifan Wang, Xiaobin Wang, Liang Zhao, Yongting Luo, Peng An, Liwei Zhang and 21 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Nutrients · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Xiaoxue LiuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0000-0002-2490-4704
Yuan HuangCardiac Surgery Centre, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Peking Union Medical College Beijing China.ORCID https://orcid.org/0000-0002-1420-8932
Yixuan LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Juan ChenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0009-0003-9792-7995
Xifan WangDepartment of Obstetrics and Gynecology Columbia University New York USA.
Xiaobin WangDivision of General Pediatrics & Adolescent Medicine, Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA.
Liang ZhaoCollege of Food Science & Nutritional Engineering China Agricultural University Beijing China.
Yongting LuoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Peng AnKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Liwei ZhangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Chengying ZhangDepartment of General Practice The Third Medical Center of Chinese PLA General Hospital (Total Hospital of the Chinese People's Armed Police Force) Beijing China.
Weijing BianDepartment of Nephrology, Beijing Anzhen Hospital Capital Medical University Beijing China.
Xingen LeiDepartment of Animal Science Cornell University, Ithaca New York USA.
Xiang GaoDepartment of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition Fudan University Shanghai China.
Yinghua LiuDepartment of Nutrition The First Medical Center of Chinese PLA General Hospital Beijing China.
Yanling HaoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Huiyuan GuoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0000-0003-0792-177X
Xiaoxu ZhangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Pengjie WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Ran WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0000-0001-7125-5690
Hao ZhangCollege of Food Science & Nutritional Engineering China Agricultural University Beijing China.
Bing FangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Xiaolin ZhangCollege of Food Science & Nutritional Engineering China Agricultural University Beijing China.
Longjiao WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Qinglu QiuCollege of Food Science & Nutritional Engineering China Agricultural University Beijing China.
Yuchan ZhangCollege of Food Science & Nutritional Engineering China Agricultural University Beijing China.
Jingyi QiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Songtao YangChina Aerospace Science & Industry Corporation 731 Hospital Beijing China.
Yulong YinYuelushan Laboratory Changsha China.
Fazheng RenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0000-0001-6250-0754
Xiaoyu WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0000-0003-0242-8943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Randomized double-blind trials have shown that probiotic mixtures significantly increase high-density lipoprotein (HDL) levels and reduce the risk of cardiovascular disease mortality in end-stage renal disease (ESRD) patients. Meta-analysis with prospective cohort studies further confirms that elevated HDL is a protective factor for ESRD outcomes. In severe renal injury models, including 5/6 nephrectomy and apolipoprotein E-deficient (

Identifiers

PMID40860441
PMCPMC12371253

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.