Evidence map›Paper›PMID 40860479›Full record

ArticleFrontiers in nutrition2025

Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet.

Chinmayee Panda, Ralph Kruse, Kaya Williams, Brea Nance, Maruti Gudavalli, Shirin Pourafshar, Brandon Metzger, Slavko Komarnytsky

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05877365 (Effects of Standard Process's 21-day Guided Purification Program on Metabolic Health in College Setting), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05877365 nacompletednot on this map

Effects of Standard Process's 21-day Guided Purification Program on Metabolic Health in College Setting

TypeinterventionalSponsorStandard Process Inc.Ran2023 to 2024Enrolled32ConditionsHealthyArmsStandard Process 21-Day Purification Program
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chinmayee PandaNutrition Innovation Center, Standard Process Inc., Kannapolis, NC, United States.
Ralph KruseKeiser University, College of Chiropractic Medicine, West Palm Beach, FL, United States.
Kaya WilliamsNutrition Innovation Center, Standard Process Inc., Kannapolis, NC, United States.
Brea NanceNutrition Innovation Center, Standard Process Inc., Kannapolis, NC, United States.
Maruti GudavalliKeiser University, College of Chiropractic Medicine, West Palm Beach, FL, United States.
Shirin PourafsharNutrition Innovation Center, Standard Process Inc., Kannapolis, NC, United States.
Brandon MetzgerNutrition Innovation Center, Standard Process Inc., Kannapolis, NC, United States.
Slavko KomarnytskyPlants for Human Health Institute, NC State University, Kannapolis, NC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A healthy diet helps transition individuals towards numerous long-term metabolic benefits but is challenging to maintain. Supplementation with additional whole food-based concentrates and herbs may support this shift by enhancing metabolic resilience. This randomized, controlled, crossover study evaluated a 21-day purification program emphasizing plant foods and whole food supplementation on metabolic detoxification, oxidative stress, and gut microbiota composition. Participants followed a plant-based diet for 7 days, with lean proteins introduced from days 8-21. Whole food supplements rich in polyphenols, glucosinolates, and prebiotic fibers were included to support metabolic and gastrointestinal function. The intervention group exhibited 9% ( Clinical trial registration: NCT05877365.

Indexed as

botanicaldetoxificationgut microbiotahealthier lifestylemetabolic healthoxidative stressplant-based dietwhole food

Identifiers

PMID40860479
PMCPMC12376428

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.