SynthesisFrontiers in nutrition2025
Predictive value of prognostic nutritional index for the long-term prognosis of elderly patients with fracture: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Prognostic Nutritional Index is a Superior Predictor to Geriatric Nutritional Risk Index for 1-Year Mortality in Older Adult Patients with Proximal Femoral Fractures.Calcified tissue international · 2026Article
- Prognostic nutritional index at admission predicts 90-day mortality in patients aged ≥80 years with hip fracture: a system-level readout of the nutrition-immune milieu relevant to microenvironment-responsive bone repair.Frontiers in medicine · 2026Article
- Predicting 90-Day Mortality After Geriatric Hip Fracture Using Combined Preoperative and Perioperative Risk Factors.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Article
- Development and validation of a nutrition-integrated nomogram for predicting 28-day mortality in sepsis patients.Frontiers in nutrition · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To present the most recent and comprehensive systematic review and meta-analysis assessing the predictive value of prognostic nutritional index (PNI) for the long-term outcomes of elderly patients with fractures. Methods: We systematically searched PubMed, Cochrane, Embase and Web of Science up to July, 2025 for studies assessing the predictive value of PNI for the long-term prognosis of elderly patients with fractures. The primary outcome measured was mortality. Odds ratios (ORs) and 95% confidence intervals (CIs) were used for data pooling. Additionally, sensitivity and subgroup analyzes were performed to assess the stability of the results and identify potential sources of heterogeneity. All analyzes were performed using Review Manger 5.4 and STATA 15.1. Results: Eight studies encompassing 11,576 elderly individuals were included for meta-analysis. The meta-analysis demonstrated that mortality was notably lower in individuals with high PNI compared to those with low PNI (OR: 0.75; 95% CI: 0.66, 0.85; Conclusion: PNI can effectively predict the long-term mortality in elderly individuals with fractures. Considering the limitations of this article, future large-scale, multicenter prospective cohort studies are still required to evaluate the prognostic value of PNI in senior patients with fractures and its influencing factors. Systematic review registration: PROSPERO, identifier CRD420251047385.
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