ArticlePeerJ2025
Effects of
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of Gallic Acid Supplementation on Intestinal Function and Gut Microbial Community Structure inAquaculture nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Brown algae polysaccharides (BAPs), derived from marine brown algae, represent bioactive macromolecules with potential functional feed applications as novel feed additives for improving the health and nutritional quality of aquatic animals. Previous studies have shown that BAPs possess antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, and antiviral activities. BAPs extracted from Methods: This study investigated the effects of UPS by supplementing juvenile sea cucumbers with 0%, 0.5%, 1%, 1.5%, 2%, and 3% UPS (polysaccharide/sea cucumber biomass, W/W). After 60 days feeding, the nutritional composition of body wall, digestive capacity and immune performance were analyzed. The diversity of intestinal microbiota in sea cucumber was analyzed using 16S rRNA gene sequence amplification technology to elucidate the effects of UPS supplementation on the composition and function of intestinal microorganisms. Results: It was demonstrated that UPS supplementation significantly increased the nutritional content of the juvenile sea cucumber body wall although growth performance remained unchanged. The polysaccharide content peaked at 1% supplementation of UPS, which was 1.6-fold higher than that of the control group. Moreover, UPS also enhanced intestinal digestive enzyme activity such as cellulase or lipase activity, which was maximized at 1% or 3% supplementation with 5.8-fold and 1.6-fold higher than that of the control group. Additionally, UPS could improve immune performance of juvenile sea cucumber by significantly elevating superoxide dismutase activity (T-SOD). It was worth noting that low UPS concentrations (1% and 1.5%) reduced malondialdehyde (MDA) content while high concentrations (2% and 3%) increased it, indicating that low UPS supplementation may had a better effect on immune performance. 16S rRNA gene sequencing revealed that UPS supplementation reduced pathogenic
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.