SynthesisPeerJ2025
The effects of exercise on oxidative stress MDA and SOD in patients with type 2 diabetes: a systematic review and meta-analysis.
Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Exercise-associated changes in leptin and irisin relate to cognitive function in older adults stratified by cognitive impairment.Scientific reports · 2026Article
- Tripterygium Glycosides Extract-Induced Hepatic Cholestasis: A Mechanistic Study Using a Microfluidic Liver-on-a-Chip System.International journal of molecular sciences · 2026Article
- Latest advances and controversies of exercise therapy in the management of type 2 diabetes.Frontiers in endocrinology · 2026Review
- 4-Methylesculetin Ameliorates Hepatic Insulin Resistance in HepG2 Cells Through AMPK/FOXO1, PI3K/AKT/GSK3β Pathways and SIRT1/NOX4 Axis.Journal of diabetes research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Systematic review of the effect of exercise intervention on oxidative stress in patients with type 2 diabetes mellitus (T2DM). Methods: Databases such as Embase, Web of Science, PubMed, The Cochrane Library, Wanfang, VIP, and China National Knowledge Infrastructure were searched from their inception to June 2024. PEDro was used to assess the quality of the literature, RevMan 5.4.1 and Stata 17.0 were used to perform meta-analysis and publication bias tests, respectively, and GRADEPro was used to evaluate the quality of the evidence for outcome indicators. Standardized mean difference (SMD) and 95% confidence interval (CI) were used as effect measures. Results: This study included 11 articles (1,111 patients). The results of the meta-analysis showed that exercise can improve malondialdehyde (MDA), standardized mean difference (SMD) = -1.29, 95% CI [-1.87 to -0.71], Discussion: This study included 11 articles with an average PEDro score of 6.5, indicating good quality. Subgroup and sensitivity analyses of the oxidative stress indicators MDA and SOD failed to identify sources of heterogeneity, which is a limitation. Publication bias tests for the oxidative stress indicators MDA and SOD suggest that there is no significant publication bias. Therefore, moderate-quality evidence is given to the oxidative stress indicator MDA, and high-quality evidence is given to the oxidative stress indicator SOD. Exercise has a significant effect on improving oxidative stress indicators MDA and SOD in patients with type 2 diabetes. It is affected by the patient's age, the method, duration, and frequency of the intervention. It can provide evidence-based medical evidence for the clinical rehabilitation of patients with type 2 diabetes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.