Evidence map›Paper›PMID 40860911›Full record

ArticleFrontiers in veterinary science2025

Melatonin ameliorates zearalenone-induced ovarian damage in mice through antioxidative effects.

Yi Song, Zhong Guo, Lei Song, Jianxiu Ma, Zhifang Zhao, Yanqing Ma, Xiaoyue Ma, Wenjie Jiang, Wanjing Wang, Chongran Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yi SongCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Zhong GuoMedical College of Northwest Minzu University, Lanzhou, China.
Lei SongMedical College of Northwest Minzu University, Lanzhou, China.
Jianxiu MaMedical College of Northwest Minzu University, Lanzhou, China.
Zhifang ZhaoMedical College of Northwest Minzu University, Lanzhou, China.
Yanqing MaMedical College of Northwest Minzu University, Lanzhou, China.
Xiaoyue MaMedical College of Northwest Minzu University, Lanzhou, China.
Wenjie JiangMedical College of Northwest Minzu University, Lanzhou, China.
Wanjing WangMedical College of Northwest Minzu University, Lanzhou, China.
Chongran LiuMedical College of Northwest Minzu University, Lanzhou, China.
Tongtong WeiMedical College of Northwest Minzu University, Lanzhou, China.
Ling FuMedical College of Northwest Minzu University, Lanzhou, China.
Zhengli QiMedical College of Northwest Minzu University, Lanzhou, China.
Jin ZhaoCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Zearalenone (ZEN), a mycotoxin from Methods: Female mice were exposed to ZEN (0.8mg/kg) with or without MT (10, 20, or 40 mg/kg) for 28 days. Ovarian morphology, hormone levels, oxidative stress markers, and DNA damage proteins were assessed. GRM02 cells were treated with ZEN (60 μM) and/or MT (100 μM). Apoptosis, cell cycle, oxidative stress, and DNA damage markers were evaluated. ATM-knockout and ATM-activated GRM02 models were used to examine pathway involvement. Results: ZEN caused ovarian atrophy, estrous disruption, reduced E2, FSH, and LH, elevated oxidative stress, and increased γH2AX, pATM, Chk2, and p53 expression. MT restored ovarian function, improved antioxidant capacity, and reduced DNA damage. In GRM02 cells, MT mitigated ZEN-induced G2/M arrest, apoptosis, and oxidative stress. ATM activation enhanced MT's protective effect, while ATM knockout worsened ZEN toxicity. Discussion: MT protects against ZEN-induced ovarian and cellular damage by reducing oxidative stress and modulating the ATM-Chk2-p53 pathway. These findings highlight MT's potential as a protective feed additive against mycotoxin-related reproductive toxicity.

Indexed as

ATM-Chk2-P53 signaling pathwaymelatoninovarianoxidative stresszearalenoneγH2AX

Identifiers

PMID40860911
PMCPMC12376198

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.