ArticleJournal of inflammation research2025
Association Between Triglyceride-Glucose Index and Malignant Risk in Thyroid Nodules: A Cross-Sectional Analysis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Association between the composite CRP-TyG index and incident malignancy risk in hospitalized patients with diabetes: a retrospective cohort study with nonlinear effect analysis.Frontiers in oncology · 2026Article
- Comment on "Association Between Triglyceride-Glucose Index and Malignant Risk in Thyroid Nodules: A Cross-Sectional Analysis" [Letter].Journal of inflammation research · 2025Article
- A study on the correlation of thyroid nodules with METS-IR and SII in a population undergoing health checkups.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this study is to investigate the association between the Triglyceride-Glucose (TyG) index and papillary thyroid carcinoma (PTC) risk, with a particular focus on metabolic, thyroid function, and immunological mechanisms. Methods: A cross-sectional study involving 1,833 participants, including 823 individuals with benign thyroid nodules and 1,010 individuals with PTC, was conducted. The TyG index was calculated using the formula ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate logistic regression analyses were performed to evaluate the association between the TyG index and PTC risk, with adjustments made for potential confounders. Results: The mean age of participants in the PTC group was 47.36 ± 12.12 years and the BTN group was 44.28 ± 10.95 years. In the unadjusted model, the TyG index demonstrated a positive correlation with PTC risk (OR = 1.67, 95% CI: 1.33-2.09, Conclusion: The TyG index alone does not serve as an independent risk factor for PTC; however, the interaction between metabolic dysfunction, thyroid function, and immune markers contributes to thyroid carcinogenesis, providing valuable insights for future research and personalized screening strategies.
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Registered trials
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