Evidence map›Paper›PMID 40860941›Full record

ArticleJournal of inflammation research2025

Berberine Inhibits Acne-Related Lipid Secretion and Inflammation by Regulating the hsa-miR-3150a-3p/TP53 Pathway.

Tonghui Li, Xiaoyue Yang, Xiaoli Wang, Shaodong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tonghui LiPharmacy Department, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, People's Republic of China.
Xiaoyue YangPharmacy Department, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, People's Republic of China.
Xiaoli WangPharmacy Department, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, People's Republic of China.
Shaodong XuPharmacy Department, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acne is a common skin illness that damages both the appearance and mental health of sufferers. Objective: The purpose of this study was to investigate the therapeutic value of berberine (BBR) in acne. Methods: Firstly, TP53 was mined to be the hub gene through network pharmacology. Then, hsa-miR-3150a-3p was predicted to be the upstream miRNA of TP53 by the ENCORI/starBase database, and their expressions and targeting relationship were verified by RT-qPCR/Western blot and dual-luciferase reporter experiment, respectively. Overexpressing hsa-miR-3150a-3p and TP53 to investigate their roles in lipid secretion and inflammation of biofilm-derived Results: Hsa-miR-3150a-3p inhibited TP53 expression by targeting its 3'UTR. BBR hindered Conclusion: BBR alleviated acne symptoms caused by Bio-

Indexed as

berberineCutibacterium acnesinflammationlipid secretionsebocytes

Identifiers

PMID40860941
PMCPMC12377369

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.