Triple-mode point-of-care diagnostics for high-risk human papillomavirus in urine.

Duc Anh Thai, Jing Liu, Angel Gutierrez Ruiz, Yuqian Zhang, Marina Walther-Antonio, Yuguang Liu

Abstract read

In one paragraph

Article in Biosensors & bioelectronics: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Duc Anh ThaiDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.

Jing LiuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.

Angel Gutierrez RuizDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.

Yuqian ZhangDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.

Marina Walther-AntonioMicrobiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

Yuguang LiuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.

Funding

Deciphering microbial-immune cell interaction using single cell approachesR35GM146651 · NIGMS · MAYO CLINIC ROCHESTER · PI Yuguang Liu · 2022 to 2026

$2.0M

NIGMS NIH HHS R35 GM146651

6 · The paper itself

Abstract

Human papillomavirus (HPV) screening is crucial for early diagnosis and prevention of cervical cancer, yet fast and convenient HPV detection remains challenging, especially in resource-limited areas. Herein, we developed a nucleic acid test named SSMG-LAMP, which combined loop-mediated isothermal amplification (LAMP) with an engineered DNA indicator (SYBR Safe - Malachite Green) for the point-of-care diagnosis of high-risk HPV strains (HPV 16 and 18) in urine. The assay can be completed within 45 min, including DNA extraction, SSMG-LAMP reaction, and signal readout using a simple, portable system. This system enabled the triple-mode detection of DNA targets using colorimetry, fluorometry, and electrochemistry, and can detect as low as 10 copies μL

Indexed as

Cervical cancerHuman papillomavirusLoop-mediated isothermal amplificationPoint-of-careTriple-mode detection

Identifiers

PMID40861161

DOI10.1016/j.biosx.2025.100658

PMCPMC12377189

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.