Evidence map›Paper›PMID 40861307›Full record

ArticleSchizophrenia bulletin open2025

Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program.

Jean Addington, Lu Liu, Monica Chu, Karl Jungert, Nora Penzel, Ofer Pasternak, Emily Farina, Ricardo E Carrion, Cheryl M Corcoran, Vijay A Mittal and 73 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

83 authors.

Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Lu LiuDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Monica ChuDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Karl JungertDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Nora PenzelDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, United States.
Ofer PasternakDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, United States.
Emily FarinaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Ricardo E CarrionNorthwell, Glen Oaks, NY 11004, United States.
Cheryl M CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston, IL 60201, United States.ORCID https://orcid.org/0000-0001-9017-5119
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA 30602, United States.
Alison R YungInstitute of Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, 3220, Australia.
Luis AlamedaNational Psychosis Unit, South London and Maudsley NHS Foundation Trust, London, SE5 8AF, United Kingdom.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, 28009 Madrid, Spain.
Owen BordersDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Sylvain BouixDepartment of Software Engineering and Information Technology, École de Technologie Supérieure, Montréal, QC HC3 1K3, Canada.
Nicholas J K BreitbordeDepartment of Psychiatry and Behavioral Health, Early Psychosis Intervention Center (EPICENTER), College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Matthew R BroomeInstitute for Mental Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
Kristin S CadenheadUniversity of California, San Diego, La Jolla, CA 92104, United States.ORCID https://orcid.org/0000-0002-5952-4605
Rolando I Castillo-PassiDepartment of Psychiatry, University of Chile, 833011 Santiago, Chile.
Eric Yu Hai ChenDepartment of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health Network, Hartford, CT 06106, United States.
Michael J ColemanDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Philippe ConusGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, 1003 Lausanne, Switzerland.
Covadonga M Diaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, 28009 Madrid, Spain.ORCID https://orcid.org/0000-0001-8538-3175
Lauren M EllmanDepartment of Psychology & Neuroscience, Temple University, Philadelphia, PA 19122-6085, United States.
Paolo Fusar PoliDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, SE5 8AF, United Kingdom.
Pablo A GasparDepartment of Psychiatry, University of Chile, 833011 Santiago, Chile.
Carla GerberPrevention Science Institute, University of Oregon, Eugene, OR 97401, United States.
Louise Birkedal GlenthøjVIRTU Research Group, Mental Health Copenhagen, University of Copenhagen, 2900 Copenhagen, Denmark.
Leslie E HortonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
Christy Lai Ming HuiDepartment of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.
Joseph KambeitzDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.ORCID https://orcid.org/0000-0002-8988-3959
Lana Kambeitz-IlankovicDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Tina KapurDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
Sinead KellyDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Melissa J KerrOrygen, Parkville, VIC, 3052  Australia.
Matcheri S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
Minah KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul 03082, South Korea.
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju 61469, South Korea.ORCID https://orcid.org/0000-0002-6739-2163
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, 80336 Munich, Germany.
Jun Soo KwonDepartment of Psychiatry, Seoul National University College of Medicine, Seoul 03080, South Korea.ORCID https://orcid.org/0000-0002-1060-1462
Kerstin LangbeinDepartment of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany.
Kathryn E LewandowskiPsychotic Disorders Division, McLean Hospital, Belmont, MA 02478, United States.
Daniel MamahDepartment of Psychiatry, Washington University Medical School, St. Louis, MO 63110, United States.
Patricia J MarcyNorthwell, Glen Oaks, NY 11004, United States.
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94121, United States.
Catalina MourguesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Merete NordentoftVIRTU Research Group, Mental Health Copenhagen, University of Copenhagen, 2900 Copenhagen, Denmark.
Angela R NunezDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Godfrey D PearlsonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Jesus PerezCAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, Cambridgeshire, CB4 1PX, United Kingdom.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States.
Albert R PowersDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.ORCID https://orcid.org/0000-0003-3057-5043
Jack RogersInstitute for Mental Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
Fred W SabbPrevention Science Institute, University of Oregon, Eugene, OR 97401, United States.
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
Johanna Seitz-HollandDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, United States.
Jai L ShahDouglas Research Centre, Montréal, QC H4H 1R3, Canada.ORCID https://orcid.org/0000-0002-7549-6990
Steven M SilversteinDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, United States.ORCID https://orcid.org/0000-0002-0699-0960
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany.
William S StoneDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School, Boston, MA 02115, United States.ORCID https://orcid.org/0000-0003-2932-7288
Judy L ThompsonDepartments of Psychiatry and Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, United States.
Rachel UpthegroveInstitute for Mental Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
Swapna VermaInstitute of Mental Health, 539747, Singapore.
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 20030, China.
Daniel H WolfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19063, United States.
Tianhong ZhangDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China.ORCID https://orcid.org/0000-0002-5379-7119
Lauren AddamoOrygen, Parkville, VIC, 3052  Australia.
Kate BuccilliOrygen, Parkville, VIC, 3052  Australia.
Dominic DwyerOrygen, Parkville, VIC, 3052  Australia.ORCID https://orcid.org/0000-0003-3949-5867
Sophie ToddOrygen, Parkville, VIC, 3052  Australia.
Youngsun T ChoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Clara FontenauDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Zailyn TamayoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Carrie E BeardenDepartments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior; University of California, Los Angeles, Los Angeles, CA 90095,  United States.ORCID https://orcid.org/0000-0002-8516-923X
John M KaneDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine, Hempstead, NY 11549, United States.ORCID https://orcid.org/0000-0002-2628-9442
Patrick D McGorryOrygen, Parkville, VIC, 3052  Australia.
Rene S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Martha E ShentonDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, United States.
Scott W WoodsDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.
Accelerating Medicines Partnership® Schizophrenia Nelson Barnaby
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19063, United States.ORCID https://orcid.org/0000-0002-0546-0263

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This paper focuses on the baseline clinical characterization of the participants in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program. The AMP SCZ program is designed to investigate a wide array of clinical variables and biomarkers in a total of 2040 clinical high-risk (CHR) participants and 652 community control (CC) participants. Methods: The dataset analyzed includes 1642 individuals at clinical high risk for psychosis and 519 CCs. Key measures include the Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the Structured Interview for Psychosis-Risk Syndromes, which determined CHR criteria and the severity of attenuated psychotic symptoms (APS). Other measures included the Structured Clinical Interview for DSM-5, scales to assess negative symptoms, depression, suicidal ideation, substance use, social and role functioning, and a selection of patient-reported outcomes. Results: CHR participants presented with more severe ratings on all clinical measures and poorer functioning relative to the CC. There were a few significant small associations between measures of APS and other clinical measures. Conclusion: The results from this study support previous research indicating that CHR individuals face serious clinical challenges beyond the risk of developing psychosis. Findings indicate significant associations among various clinical measures, underscoring the complex nature of the CHR population. Limitations are acknowledged, including the preliminary nature of the data and the need for more in-depth analyses from AMP SCZ papers already in progress. Future work will focus on longitudinal data and further exploration of clinical variables and their relationship with biomarkers.

Indexed as

AMP SCZassessmentsclinical high riskclinical outcomescommunity controlspsychosis

Identifiers

PMID40861307
PMCPMC12377803

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.