ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Association between the dietary index for gut microbiota and Alzheimer's disease: A cross-sectional study from the National Health and Nutrition Examination Survey (2004 to 2018).
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The influence of depression onset timing after gastrointestinal diseases on dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association between the dietary index for gut microbiota and Alzheimer's disease: A cross-sectional study from the National Health and Nutrition Examination Survey (2004 to 2018).Alzheimer's & dementia (Amsterdam, Netherlands)Article
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2 authors.
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Abstract
introductionEmerging evidence implicates gut microbiota (GM), shaped by diet, in Alzheimer's disease (AD) pathogenesis. However, the association between the dietary index for GM (DI-GM) and AD remains unclear.
methodsThis cross-sectional study analyzed data from 28,830 adults aged ≥20 years in the 2004-2018 National Health and Nutrition Examination Survey (NHANES). The DI-GM score, derived from dietary recalls, comprised beneficial to GM score (BGMS) and unfavorable to GM score (UGMS) components. AD was identified via self-report, medications, or death certificates. Multivariable weighted logistic regression, restricted cubic spline, and subgroup analyses were performed.
resultsContrary to expectations, higher DI-GM score and UGMS were associated with increased AD prevalence (DI-GM: odds ratio [OR] = 1.24, 95% CI: 1.02 to 1.52, DISCUSSION: The DI-GM was positively associated with AD prevalence, suggesting that imbalanced plant-based diets low in protein or key nutrients may elevate AD risk despite presumed microbiota benefits. Highlights: Higher DI-GM and UGMS were significantly associated with greater AD prevalence in US adults.Restricted cubic spline analyses showed linear and non-linear associations of DI-GM and UGMS with AD, respectively.Results challenge prior assumptions that higher DI-GM scores are uniformly linked to health benefits.Imbalanced plant-based diets low in protein or key nutrients may adversely affect cognitive aging despite presumed microbiota benefits.
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