SynthesisFrontiers in microbiology2025
Gut microbiota regulate atherosclerosis via the gut-vascular axis: a scoping review of mechanisms and therapeutic interventions.
Synthesis in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Psyllium and Glucomannan as Viscous Fiber Modulators of the Gut-Microbiome-Incretin Axis: Molecular Links to Metabolic Inflammation, Barrier Function, and GLP-1 Receptor Agonist Therapy.International journal of molecular sciences · 2026Review
- Vascular Aging and Atherosclerosis: The Modulatory Impact of Selenium-A Comprehensive Review.Cells · 2026Review
- Host-Microbiota Metabolic Interactions in Atherosclerosis: Oral, gut, and Blood Perspectives.Probiotics and antimicrobial proteins · 2026Review
- Microbiota-mediated mechanisms of natural products in atherosclerosis: focus on metabolic and inflammatory pathways.Frontiers in endocrinology · 2026Review
- PANoptosis links gut dysbiosis to obstructive sleep apnea-associated atherosclerosis: a gut-vascular inflammatory axis.Frontiers in immunology · 2026Review
- Microbiota-Driven Immune Dysregulation Along the Gut-Lung-Vascular Axis in Asthma and Atherosclerosis.Biomedicines · 2025Review
- Bitter taste receptors in the gut-vascular axis: a novel target for immune and metabolic regulation of hypertension.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Atherosclerosis (AS) is a chronic inflammatory and metabolic disease, and advancements in its treatment have long been hampered by the complexity of its underlying mechanisms. The newly proposed "gut-vascular axis" theory holds promise for systematically elucidating the interactions between gut microbiota (GM) and vascular homeostasis. This provides a novel research framework for formulating precise preventive and therapeutic strategies against AS. Objective: To explore the mechanisms by which GM and their metabolites regulate AS via the gut-vascular axis, and the potential application of intervention strategies targeting this axis in the prevention and treatment of AS. Methods: Following the methods of a scoping review, we searched the databases Cochrane Library, Embase, PubMed and Web of Science, and the search period was from January 1, 2014, to July 25, 2024. Two researchers individually reviewed the basic characteristics of the included studies. Results: A total of articles were retrieved, identified 3556 articles and 192 of which were ultimately included in the study. The results are divided into three main sections, including the impact of GM and gut microbial metabolites (GMMs) on AS, and how various intervention factors can influence AS by influencing the composition of the GM. Conclusion: Based on the gut-vascular axis theory, a multi-target combined intervention strategy has been proposed, encompassing probiotics/prebiotics regulation and precise nutritional interventions, thereby establishing novel approaches for AS prevention and treatment. Future research should prioritize the integration of artificial intelligence (AI) with multi-omics technologies to comprehensively decipher the interaction mechanisms between microbial metabolic networks and vascular pathologies within the gut-vascular axis framework. This interdisciplinary approach will promote the advancement of AS management toward emerging personalized precision medicine. Systematic review registration: 10.17605/OSF.IO/X8WQM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.