ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Orbital Fat is an Observation Model to Provide Insights into Adipocyte Hypertrophy and Hyperplasia During White Adipose Tissue Expansion.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Precision Nutrition in Type 2 Diabetes Prevention Through Molecular Nutrigenomic and Epigenetic Modulation of Insulin Signaling and Glucose Metabolism.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Obesity is a global health problem characterized by excessive white adipose tissue (WAT) distribution. Adipocyte hypertrophy (increased cell size) and hyperplasia (differentiation into new adipocytes from pre-adipocytes) are two ways for WAT to expand. The precedence of hypertrophy over hyperplasia leads to an enlarged adipocyte size, which is associated with multiple metabolic dysfunctions. Compared with abdominal subcutaneous fat (SF), orbital fat (OF) has smaller adipocytes with less inflammatory infiltration, better vascularization, and higher adipogenic and proliferative capacities, reflecting a healthy metabolic state. Polyunsaturated fatty acids (PUFAs) can stabilize energy homeostasis via G protein-coupled receptor 120 (GPR120) to alleviate insulin resistance and inflammation. Methods: We used lipidomics analysis to reveal a greater accumulation of two PUFAs-arachidonic acid (AA) and docosapentaenoic acid (DPA) in OF than in SF and then hypothesized that AA/DPA is one factor regulating WAT morphological and biological heterogeneity. Results: Mechanistically, the existing literature evidence suggests that AA/DPA signals may stimulate the co-activation and interaction of GPR120 and peroxisome proliferator-activated receptor γ (PPARγ), at least partially contributing to adipose metabolic health. Conclusion: As the differential metabolites between OF and SF, AA and DPA, along with the relevant GPR120/PPARγ pathways, offer new therapeutic approaches for morbid obesity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.