Evidence map›Paper›PMID 40862723›Full record

ReviewCells2025

Lipoxins as Modulators of Diseases.

Uzma Saqib, Monika Pandey, Anjali Vyas, Preeti Patidar, Sumati Hajela, Asgar Ali, Meenakshi Tiwari, Sutripta Sarkar, Neelam Yadav, Shivani Patel and 9 more

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Anti-Inflammatory Effects of Lipoxin A4 inAnimals : an open access journal from MDPI · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Uzma SaqibSchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road Campus, Indore 452001, Madhya Pradesh, India.
Monika PandeySchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road Campus, Indore 452001, Madhya Pradesh, India.
Anjali VyasSchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road Campus, Indore 452001, Madhya Pradesh, India.
Preeti PatidarDr. Vikram Sarabhai Institute of Cell and Molecular Biology, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Sumati HajelaDepartment of Biotechnology, Mahakaushal University, Jabalpur 482003, India.
Asgar AliDepartment of Biochemistry, All India Institute of Medical Sciences, Patna 801507, Bihar, India.ORCID 0000-0003-2153-5066
Meenakshi TiwariDepartment of Center for Advance Research, King George's Medical University, Lucknow 226003, Uttar Pradesh, India.
Sutripta SarkarPost Graduate Department of Food and Nutrition, Barrackpore Rastraguru Surendranath College, Kolkata 700120, West Bengal, India.
Neelam YadavSchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road Campus, Indore 452001, Madhya Pradesh, India.
Shivani PatelSchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road Campus, Indore 452001, Madhya Pradesh, India.
Deepali ShuklaDepartment of Microbiology, College of Life Sciences, Cancer Hospital and Research Institute, Gwalior 474009, Madhya Pradesh, India.ORCID 0000-0001-8898-8532
Grace N LienemannDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Fletcher A WhiteDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8408-9262
Herney Andrés García-PerdomoUROGIV Research Group, Department of Surgery, School of Medicine, Universidad del Valle, Cali 72824, Colombia.ORCID 0000-0001-6945-8261
Mirza Saqib BaigMehta Family School of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IITI), Indore 453552, Madhya Pradesh, India.
Ganesh V HaladeHeart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Tampa, FL 33602, USA.
Krishnan HajelaSchool of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road Campus, Indore 452001, Madhya Pradesh, India.
Sadhana SharmaDepartment of Biochemistry, All India Institute of Medical Sciences, Patna 801507, Bihar, India.ORCID 0000-0002-2400-0051
Alexander G ObukhovDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-3862-6004

Funding

The role of cell-specific TLR-4 signaling in oxaliplatin-induced peripheral neuropathyR01NS102415 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WHITE, FLETCHER A · 2018 to 2022
$2.2M
Novel treatments of fracture repair and bone painR01AR083130 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Melissa A Kacena, Alexander G. Obukhov · 2024 to 2026
$1.7M
American Heart Association 24IVPHA1299211American Heart Association 25IVPHA1475095NIAMS NIH HHS R01 AR083130NIH HHS 1R01NS102415-24NIH HHS 2R01AR083130-25NINDS NIH HHS R01 NS102415
6 · The paper itself

Abstract

Lipoxins were discovered 40 years ago, and since then, their beneficial roles for human health have been confirmed in numerous studies. These small molecules belong to the eicosanoid class of compounds, which are generated metabolically by lipoxygenases. Lipoxins are released during various diseases and conditions, including but not limited to systemic inflammation, infection, asthma, cancer, diabetes, and cardiovascular disorders. Recently, several synthetic lipoxin analogs have been developed that also exhibit potent anti-inflammatory properties. In this review, we discuss the inflammation-resolving roles of lipoxins in various major diseases. Further, we summarize the latest reports on the use of synthetic lipoxins as potential therapeutic agents and discuss the role of aspirin-dependent lipoxin production in alleviating various diseases, including cancer.

Indexed as

LipoxinsAnimalsHumansInflammationNeoplasmsLipoxinseicosanoidshost defenseimmunomodulationinflammationlipoxinslipoxygenasessynthetic lipoxinstherapeutic agents

Identifiers

PMID40862723
PMCPMC12385082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.