ArticleCells2025
Single-Cell mRNA Analysis for the Identification of Molecular Pathways of IRF1 in HER2+ Breast Cancer.
Laura Vilardo, Paride Pelucchi, Antonia Brindisi, Edoardo Abeni, Eleonora Piscitelli, Ettore Mosca, Giovanni Bertalot, Mira Palizban, Theodoros Karnavas, Angelos D Gritzapis and 4 more
Abstract read
In one paragraphArticle in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Laura VilardoInstitute of Biomedical Technologies, National Research Council, 20054 Milano, Italy.
Paride PelucchiInstitute of Biomedical Technologies, National Research Council, 20054 Milano, Italy.ORCID 0000-0001-5415-1515 Antonia BrindisiInstitute of Biomedical Technologies, National Research Council, 20054 Milano, Italy.
Edoardo AbeniInstitute of Biomedical Technologies, National Research Council, 20054 Milano, Italy.
Eleonora PiscitelliInstitute of Biomedical Technologies, National Research Council, 20054 Milano, Italy.ORCID 0000-0002-4973-1846 Giovanni BertalotUnita' Operativa Multizonale di Anatomia Patologica, APSS and Centre for Medical Sciences-CISMed, University of Trento, 38122 Trento, Italy.ORCID 0000-0002-4862-7705 Mira PalizbanDepartment of Gynecology and Obstetrics, University Hospital Muenster, D11, 48149 Muenster, Germany.
Theodoros KarnavasDepartment of Biology, Touro University, New York, NY 10023, USA.
Angelos D GritzapisCancer Immunology and Immunotherapy Center, Agios Savas Cancer Hospital, 11522 Athens, Greece.
Ioannis MisitzisAthens Medical Center, Psychiko Clinic, 11525 Athens, Greece.
Martin GötteDepartment of Gynecology and Obstetrics, University Hospital Muenster, D11, 48149 Muenster, Germany.ORCID 0000-0003-2360-2496 Ileana ZucchiInstitute of Biomedical Technologies, National Research Council, 20054 Milano, Italy.
Rolland ReinboldInstitute of Biomedical Technologies, National Research Council, 20054 Milano, Italy.
Funding
CNR project FOE-2021 DBA.AD005.225 DBA.AD005.225This research was funded by Marie Skłodowska-Curie Actions (MSCA), call HORIZON MSCA-2021-SE-01 project number 101086322 (to R.R.) project number 101086322
6 · The paper itselfAbstract
Clonally established tumor cell lines often do not recapitulate the behavior of cells in tumors. The sequencing of a whole tumor tissue may not uncover transcriptome profiles induced by the interactions of all different cell types within a tumor. Interferons for instance have a vast number of binding sites in their target genes. Access to the DNA binding sites is determined by the epigenomic state of each different cell type within a tumor mass. To understand how genes such as interferons appear to have both tumor-promoting and tumor-inhibiting functions, single-cell transcript analysis was performed in the breast cancer tissue of
Indexed as
Breast NeoplasmsErb-b2 Receptor Tyrosine KinasesInterferon Regulatory Factor-1RNA, MessengerSingle-Cell AnalysisFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansSignal TransductionERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesInterferon Regulatory Factor-1IRF1 protein, humanRNA, Messengerendoplasmic reticulumHER2+ breast cancerinterferonsIRF1rheumatoid arthritisRNASET2SDC2single-cell transcript analysisTMEM230TP53
Identifiers
PMID40862725
PMCPMC12384442
What Socratic holds
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LicenceCC BY
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