Evidence map›Paper›PMID 40862746›Full record

ArticleCells2025

Multi-Modal Profiling Reveals Contrasting Immunomodulatory Effects of Recreational Marijuana Used Alone or with Tobacco in Youth with HIV.

Samiksha A Borkar, Guglielmo M Venturi, Kai-Fen Chang, Jingwen Gu, Li Yin, Jerry Shen, Bernard M Fischer, Upasana Nepal, Isaac D Raplee, Julie J Kim-Chang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Samiksha A BorkarMolecular HIV and Host Interactions Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0000-2612-1626
Guglielmo M VenturiDivision of Allergy and Immunology, Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.
Kai-Fen ChangMolecular HIV and Host Interactions Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3893-7176
Jingwen GuBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Li YinMolecular HIV and Host Interactions Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3317-4133
Jerry ShenMolecular HIV and Host Interactions Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Bernard M FischerDivision of Allergy and Immunology, Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-8066-0516
Upasana NepalMolecular HIV and Host Interactions Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Isaac D RapleeMolecular HIV and Host Interactions Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3105-1287
Julie J Kim-ChangDivision of Allergy and Immunology, Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-9799-9054
David M MurdochDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-7201-7950
Sharon L NicholsDepartment of Neurosciences, University of California, San Diego, CA 92093, USA.
Lisa B Hightow-WeidmanInstitute on Digital Health and Innovation, College of Nursing, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-2421-923X
Charurut SomboonwitDivision of Infectious Diseases, Department of Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA.
John W SleasmanDivision of Allergy and Immunology, Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.
Maureen M GoodenowMolecular HIV and Host Interactions Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Adol. Medicine Trials Network for HIV/AIDS InterventionsU01HD040474 · NICHD · WESTAT, INC. · PI HARRIS, DONALD ROBERT · 2001 to 2016
$114.4M
LEADERSHIP GROUP FOR ADOLESCENT MEDICINE TRIALS NETWORKU01HD040533 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILSON, CRAIG M · 2001 to 2016
$76.4M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Substance Use and Immunity in HIV+ Adolescents by Systems BiologyR01DA031017 · NIDA · UNIVERSITY OF FLORIDA · PI YIN, LI · 2010 to 2014
$4.4M
Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis UsersR01DA048627 · NIDA · DUKE UNIVERSITY · PI MURDOCH, DAVID MARTIN · 2019 to 2024
$3.9M
Consequences of marijuana use on inflammatory pathways in HIV-infected youthU01DA044571 · NIDA · DUKE UNIVERSITY · PI SLEASMAN, JOHN W. · 2017 to 2021
$2.9M
NIAID NIH HHS P30 AI064518NICHD NIH HHS U01 HD040474NICHD NIH HHS U01 HD040533NIDA NIH HHS R01 DA031017NIDA NIH HHS R01 DA048627NIDA NIH HHS U01 DA044571NIH grants R01-DA031017 (MMG), U01-DA044571 (JWS), U01- HD040533 (JWS), U01-HD040474 (JWS), U01-A1068632 (JWS), 5P30-AI064518 (JWS, Duke University Center for AIDS Research), NIH Office of AIDS Research and National Institute of Allergy and Infectious Dis NIH grants R01-DA031017 (MMG), U01-DA044571 (JWS), U01- HD040533 (JWS), U01-HD040474 (JWS), U01-A1068632 (JWS), 5P30-AI064518 (JWS, Duke University Center for AIDS Research), NIH Office of AIDS Research and National Institute of Allergy and Infectious Dis
6 · The paper itself

Abstract

The evolving legal landscape has increased marijuana accessibility across the United States, including for medical use to manage clinical symptoms among people with HIV. The effects of marijuana use remain understudied in youth with HIV (YWH), who face lifelong antiretroviral therapy (ART) and an elevated risk of developing comorbidities. This study applied a multi-modal approach, including plasma biomarker analysis, peripheral blood cell phenotyping, and transcriptome profiling, to examine the effects of recreational marijuana alone, tobacco alone, or marijuana combined with tobacco in virally suppressed YWH (≤50 RNA copies/mL) on ART compared to youth without HIV and YWH who used no substance. Marijuana use alone was associated with elevated IL-10 levels and normalization of pro-inflammatory genes and pathways, suggesting an immunomodulatory effect. Conversely, tobacco use alone or combined with marijuana was linked to increased IL-1β levels and heightened pro-inflammatory responses, including upregulation of genes involved in inflammasome activation. This study is the first to demonstrate

Indexed as

CannabisHIV InfectionsImmunomodulationMarijuana UseAdolescentBiomarkersFemaleGene Expression ProfilingHumansInflammationMaleReceptors, G-Protein-CoupledYoung AdultBiomarkersReceptors, G-Protein-Coupledbiomarkersbioprofilescomorbiditiesflow cytometryimmunomodulatorymarijuanatobaccotranscriptomeyouth with HIVyouth without HIV

Identifiers

PMID40862746
PMCPMC12385114

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.