Evidence map›Paper›PMID 40862769›Full record

ReviewCells2025

The Roles of Non-Coding RNAs in the Pathogenesis of Uterine Fibroids.

Drake Boos, Tsai-Der Chuang, Omid Khorram

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Transcriptomic and functional analysis of fibroid extracellular vesicles.Clinical science (London, England : 1979) · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Drake BoosThe Lundquist Institute for Biomedical Innovation, Torrance, CA 90502, USA.
Tsai-Der ChuangThe Lundquist Institute for Biomedical Innovation, Torrance, CA 90502, USA.ORCID 0000-0003-1195-7054
Omid KhorramThe Lundquist Institute for Biomedical Innovation, Torrance, CA 90502, USA.ORCID 0000-0003-4996-5762

Funding

Tryptophan metabolism and its role in fibroid pathogenesisR01HD109286 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI OMID A. KHORRAM · 2022 to 2026
$1.9M
Mechanism of Long Non-coding RNAs Action in leiomyomaR01HD100529 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI KHORRAM, OMID A. · 2020 to 2023
$1.7M
National Institute of Health HD100529 and HD109286NICHD NIH HHS R01 HD100529NICHD NIH HHS R01 HD109286
6 · The paper itself

Abstract

Uterine fibroids are benign smooth muscle tumors that affect ~70% of women, with Black women being affected at a disproportionate rate. The growth of these tumors is driven by estrogen and progesterone. Driver mutations in genes such as MED12, HMGA2, and FH also play roles in the development and growth of fibroids. Despite their high prevalence, the pathogenesis of fibroids remains largely unknown, leading to a lack of effective therapeutic options. Non-coding RNAs (ncRNAs), including miRNAs (e.g.,

Indexed as

LeiomyomaRNA, UntranslatedUterine NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansRNA, Long NoncodingRNA, Long NoncodingRNA, UntranslatedMED12non-coding RNAuterine fibroids

Identifiers

PMID40862769
PMCPMC12384623

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.