Evidence map›Paper›PMID 40862821›Full record

ReviewCurrent oncology (Toronto, Ont.)2025

Focused Ultrasound for Sarcomas: A Narrative Review.

Nidhi Kuchimanchi, Nicolle Sul, Sai Gajula, Margaret Mercante, Emily Tocco, Mackenzie M Mayhew, Lynn T Dengel, Ludimila Cavalcante, Lauren Hadley, Russell Gardner Witt

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nidhi KuchimanchiSchool of Medicine, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0009-0004-1274-1399
Nicolle SulFocused Ultrasound Foundation, Charlottesville, VA 22903, USA.
Sai GajulaSchool of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Margaret MercanteSchool of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Emily ToccoSchool of Medicine, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0009-0004-2330-5760
Mackenzie M MayhewDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.
Lynn T DengelDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.
Ludimila CavalcanteDepartment of Medicine, University of Virginia Health System, Charlottesville, VA 22903, USA.ORCID 0000-0002-9676-0789
Lauren HadleyFocused Ultrasound Foundation, Charlottesville, VA 22903, USA.ORCID 0000-0002-4639-0345
Russell Gardner WittDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NCI NIH HHS P30 CA044579
6 · The paper itself

Abstract

Sarcomas are tumors of mesenchymal origin that are generally resistant to systemic therapies and prone to local recurrence despite current multimodal treatment approaches. Focused ultrasound (FUS) is a noninvasive therapeutic technology that may enhance standard treatment strategies for primary solid malignancies. FUS exerts its effects through diverse mechanisms, including high-intensity focused ultrasound (HIFU) thermal ablation, histotripsy, sonodynamic therapy, immunomodulation, and hyperthermia-enhanced drug delivery. In this narrative review, we summarize the mechanisms of focused ultrasound that have been investigated for the treatment of sarcomas and highlight the results of preclinical, veterinary, and clinical studies related to this area.

Indexed as

High-Intensity Focused Ultrasound AblationSarcomaUltrasonic TherapyAnimalsHumansfocused ultrasoundhistotripsyhyperthermiaimmunomodulationMRI-guided HIFUsarcomasoft tissue tumorsonodynamic therapythermal ablation

Identifiers

PMID40862821
PMCPMC12384516

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.