Evidence map›Paper›PMID 40863144›Full record

ArticleMetabolites2025

Site-Specific Trafficking of Lipid and Polar Metabolites in Adipose and Muscle Tissue Reveals the Impact of Bariatric Surgery-Induced Weight Loss: A 6-Month Follow-Up Study.

Aidan Joblin-Mills, Zhanxuan E Wu, Garth J S Cooper, Ivana R Sequeira-Bisson, Jennifer L Miles-Chan, Anne-Thea McGill, Sally D Poppitt, Karl Fraser

Abstract read
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aidan Joblin-MillsFood Chemistry and Structure, AgResearch Limited, Palmerston North 4442, New Zealand.ORCID 0009-0000-8702-5523
Zhanxuan E WuFood Chemistry and Structure, AgResearch Limited, Palmerston North 4442, New Zealand.ORCID 0000-0003-1896-0221
Garth J S CooperSchool of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.ORCID 0000-0001-5241-3163
Ivana R Sequeira-BissonHigh-Value Nutrition National Science Challenge, Auckland 1010, New Zealand.ORCID 0000-0001-5414-9925
Jennifer L Miles-ChanHigh-Value Nutrition National Science Challenge, Auckland 1010, New Zealand.ORCID 0000-0003-0313-7048
Anne-Thea McGillTe Kāika Queenstown/Ōamaru, Ōtākou Health Limited, Caversham, Dunedin 9012, New Zealand.ORCID 0000-0001-6464-4663
Sally D PoppittHigh-Value Nutrition National Science Challenge, Auckland 1010, New Zealand.ORCID 0000-0002-2214-8378
Karl FraserFood Chemistry and Structure, AgResearch Limited, Palmerston North 4442, New Zealand.ORCID 0000-0002-1136-4024

Funding

New Zealand National Science Challenge High Value Nutrition 3710040
6 · The paper itself

Abstract

backgroundThe causation of type 2 diabetes remains under debate, but evidence supports both abdominal lipid and ectopic lipid overspill into tissues including muscle as key. How these depots differentially alter cardiometabolic profile and change during body weight and fat loss is not known.

methodsWomen with obesity scheduled to undergo bariatric surgery were assessed at baseline (BL,

resultsThere was significant body weight (-24.5 kg) loss at 6m_FU (

conclusionsIn this first report on channelling of lipids and polar metabolites to alternative tissues in bariatric-induced weight loss, adaptive shuttling of small molecules was identified, further promoting adipose processing and highlighting the dynamic and coordinated nature of post-surgical metabolic regulation.

Indexed as

amino acidsJaccard–Tanimoto coefficientslaparoscopic samplesmetabolomicsmultivariate statisticsplasma

Identifiers

PMID40863144
PMCPMC12388112

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.