Evidence map›Paper›PMID 40863159›Full record

ArticleMetabolites2025

Flavonoids and Sesquiterpene Lactones from

Calisto Moreno Cardenas, Ren Ove Kratzert, Sofie Hanifle, Elida Cleyse Gomes da Mata Kanzaki, Isamu Kanzaki, Brigitte Kircher, Serhat Sezai Çiçek

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In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Calisto Moreno CardenasDepartment of Pharmaceutical Biology, Kiel University, Gutenbergstraße 76, 24118 Kiel, Germany.ORCID 0009-0001-1256-4124
Ren Ove KratzertDepartment of Pharmaceutical Biology, Kiel University, Gutenbergstraße 76, 24118 Kiel, Germany.
Sofie HanifleDepartment of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Elida Cleyse Gomes da Mata KanzakiLaboratory of Bioprospection, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, DF, Brazil.
Isamu KanzakiLaboratory of Bioprospection, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0009-0006-1143-4025
Brigitte KircherDepartment of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.ORCID 0000-0003-1624-2664
Serhat Sezai ÇiçekDepartment of Pharmaceutical Biology, Kiel University, Gutenbergstraße 76, 24118 Kiel, Germany.ORCID 0000-0002-3038-8523

Funding

Land Schleswig-Holstein Open Access Publikationsfonds
6 · The paper itself

Abstract

objectivesMultiple myeloma and acute myeloid leukemia are severe forms of blood cancer, which lack effective therapies for treatment. In our search for new chemical lead structures from nature, we were investigating the Brazilian medicinal plant arnica-do-cerrado (

methodsRepeated chromatography led to the isolation of four flavonoids and three sesquiterpenoids, which were evaluated for their cytostatic and cytotoxic properties against HL-60, MOLM-13, AMO-1, and KMS-12 PE cancer cells as well as the non-malignant HS-5 cell line.

resultsWhereas the isolated flavonoids displayed only moderate activity, the three sesquiterpene lactones goyazensolide, centratherin, and lychnopholide exhibited pronounced effects against all four tested cell lines. Goyazensolide was the most effective compound, inhibiting proliferation and metabolic activity with IC

conclusionThe results of this study revealed interesting natural products that will be further evaluated for their potential as new lead compounds for the treatment of acute myeloid leukemia and multiple myeloma.

Indexed as

arnica da serraCichorioideaecytotoxicityhematologic cancerLychnophora pinastermetabolic activitypolyphenolstructure-activity-relationshipterpenetumor

Identifiers

PMID40863159
PMCPMC12388523

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.