Evidence mapPaperPMID 40863205Full record

ArticleDiseases (Basel, Switzerland)2025

Optimizing Perioperative Care in Esophageal Surgery: The EUropean PErioperative MEdical Networking (EUPEMEN) Collaborative for Esophagectomy.

Orestis Ioannidis, Elissavet Anestiadou, Angeliki Koltsida, Jose M Ramirez, Nicolò Fabbri, Javier Martínez Ubieto, Carlo Vittorio Feo, Antonio Pesce, Kristyna Rosetzka, Antonio Arroyo and 8 more

Abstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Epidurals in esophagectomy: end of an era?Journal of thoracic disease · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Orestis IoannidisFourth Department of Surgery, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, General Hospital "George Papanikolaou", 57010 Thessaloniki, Greece.ORCID 0000-0002-0861-8783
Elissavet AnestiadouFourth Department of Surgery, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, General Hospital "George Papanikolaou", 57010 Thessaloniki, Greece.ORCID 0000-0001-5650-7319
Angeliki KoltsidaFourth Department of Surgery, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, General Hospital "George Papanikolaou", 57010 Thessaloniki, Greece.ORCID 0000-0001-5741-2071
Jose M RamirezInstitute for Health Research Aragón, 50009 Zaragoza, Spain.ORCID 0000-0001-7964-1166
Nicolò FabbriDepartment of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-7039-3717
Javier Martínez UbietoInstitute for Health Research Aragón, 50009 Zaragoza, Spain.
Carlo Vittorio FeoDepartment of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0699-5689
Antonio PesceDepartment of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-7560-551X
Kristyna RosetzkaDepartment of Plastic Surgery, Second Faculty of Medicine, Charles University, Motol University Hospital, 150 06 Prague, Czech Republic.
Antonio ArroyoDepartment of Surgery, Universidad Miguel Hernández Elche, Hospital General Universitario Elche, 03203 Elche, Spain.ORCID 0000-0003-0157-5175
Petr KociánDepartment of Surgery, Second Faculty of Medicine, Charles University, Motol University Hospital, 150 06 Prague, Czech Republic.ORCID 0000-0002-5401-1827
Luis Sánchez-GuillénDepartment of Surgery, Universidad Miguel Hernández Elche, Hospital General Universitario Elche, 03203 Elche, Spain.ORCID 0000-0003-0623-9074
Ana Pascual BellostaInstitute for Health Research Aragón, 50009 Zaragoza, Spain.ORCID 0000-0001-9440-8282
Adam WhitleyDepartment of Surgery, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic.ORCID 0000-0002-4415-172X
Alejandro Bona EnguitaInstitute for Health Research Aragón, 50009 Zaragoza, Spain.
Marta Teresa-FernandézInstitute for Health Research Aragón, 50009 Zaragoza, Spain.
Stefanos BitsianisFourth Department of Surgery, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, General Hospital "George Papanikolaou", 57010 Thessaloniki, Greece.ORCID 0000-0001-8281-1189
Savvas SymeonidisFourth Department of Surgery, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, General Hospital "George Papanikolaou", 57010 Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesDespite advancements in surgery, esophagectomy remains one of the most challenging and complex gastrointestinal surgical procedures, burdened by significant perioperative morbidity and mortality rates, as well as high financial costs. Recognizing the need for standardized care provided by a multidisciplinary healthcare team, the EUropean PErioperative MEdical Networking (EUPEMEN) initiative developed a dedicated protocol for perioperative care of patients undergoing esophagectomy, aiming to enhance recovery, reduce morbidity, and homogenize care delivery across European healthcare systems.

methodsDeveloped through a multidisciplinary European collaboration of five partners, the protocol incorporates expert consensus and the latest scientific evidence. It addresses the entire perioperative pathway, from preoperative preparation to hospital discharge and postoperative recovery, emphasizing patient-centered care, risk mitigation, and early functional restoration.

resultsThe implementation of the EUPEMEN esophagectomy protocol is expected to improve patient outcomes through a day-by-day structured prehabilitation plan, meticulous intraoperative management, and proactive postoperative rehabilitation. The approach promotes reduced postoperative complications, earlier return to oral intake, and shorter hospital stays, while supporting multidisciplinary coordination.

conclusionsThe EUPEMEN protocol for esophagectomy provides a comprehensive guideline framework for optimizing perioperative care in esophageal surgery. In addition, it serves as a practical guide for healthcare professionals committed to advancing surgical recovery and standardizing clinical practice across diverse care environments across Europe.

Indexed as

enhanced recoveryesophageal surgeryesophagectomyEUPEMENmultimodal rehabilitationperioperative careprotocol developmentsurgical optimization

Identifiers

PMID40863205
PMCPMC12385772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.