Evidence mapPaperPMID 40863379Full record

ReviewJournal of cardiovascular development and disease2025

Hybrid Ablation in Atrial Fibrillation: Bridging Mechanistic Understanding and Clinical Practice.

Flavia Ravelli, Stefano Branzoli, Alessandro Cristoforetti, Silvia Quintarelli, Alessio Coser, Paolo Moggio, Mark La Meir, Carlo de Asmundis, Luigi Pannone, Francesco Onorati and 2 more

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Flavia RavelliLaboratory of Biophysics and Translational Cardiology, Department of Cellular, Computational and Integrative Biology (CIBIO), Centre for Medical Sciences (CISMed), University of Trento, 38123 Trento, Italy.ORCID 0000-0002-7882-0709
Stefano BranzoliDepartment of Cardiac Surgery, S. Chiara Hospital, APSS PA of Trento, 38122 Trento, Italy.
Alessandro CristoforettiLaboratory of Biophysics and Translational Cardiology, Department of Cellular, Computational and Integrative Biology (CIBIO), Centre for Medical Sciences (CISMed), University of Trento, 38123 Trento, Italy.ORCID 0000-0003-1665-6656
Silvia QuintarelliDepartment of Cardiology, S. Chiara Hospital, APSS PA of Trento, 38122 Trento, Italy.ORCID 0009-0004-7939-1311
Alessio CoserDepartment of Cardiology, S. Chiara Hospital, APSS PA of Trento, 38122 Trento, Italy.
Paolo MoggioDepartment of Cardiology, S. Chiara Hospital, APSS PA of Trento, 38122 Trento, Italy.
Mark La MeirCardiac Surgery Department, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, 1050 Brussels, Belgium.
Carlo de AsmundisHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, 1050 Brussels, Belgium.
Luigi PannoneHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, 1050 Brussels, Belgium.
Francesco OnoratiDepartment of Cardiac Surgery, S. Chiara Hospital, APSS PA of Trento, 38122 Trento, Italy.
Roberto BonmassariDepartment of Cardiology, S. Chiara Hospital, APSS PA of Trento, 38122 Trento, Italy.
Massimiliano MariniDepartment of Cardiology, S. Chiara Hospital, APSS PA of Trento, 38122 Trento, Italy.ORCID 0000-0001-9388-3292

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, poses a significant burden on global morbidity and healthcare expenditure. Although endocardial catheter ablation and surgical ablation are established therapeutic strategies, each exhibits inherent limitations in achieving comprehensive substrate modification. Hybrid ablation therapy, integrating both endocardial and epicardial approaches, aims to overcome these limitations by enabling the more extensive and transmural targeting of arrhythmogenic foci and the complex atrial substrate. This review synthesizes the electrophysiological basis and mechanistic rationale underpinning hybrid AF ablation, highlighting its potential for an enhanced efficacy compared to isolated techniques. Furthermore, it introduces the emerging paradigm of three-dimensional ablation within this evolving field.

Indexed as

atrial fibrillationatrial fibrillation ablationatrial fibrillation mechanismsatrial remodelingcardiac arrhythmiashybrid ablation

Identifiers

PMID40863379
PMCPMC12387108

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.