Evidence map›Paper›PMID 40863452›Full record

ReviewJournal of personalized medicine2025

Lost in .*VCF Translation. From Data Fragmentation to Precision Genomics: Technical, Ethical, and Interpretive Challenges in the Post-Sequencing Era.

Massimiliano Chetta, Marina Tarsitano, Nenad Bukvic, Laura Fontana, Monica Rosa Miozzo

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Massimiliano ChettaA.O.R.N. A. Cardarelli Hospital's Laboratory of Medical Genetics and Genomics, 80131 Naples, Italy.ORCID 0000-0001-6300-0604
Marina TarsitanoA.O.R.N. A. Cardarelli Hospital's Laboratory of Medical Genetics and Genomics, 80131 Naples, Italy.
Nenad BukvicU.O.C Genetica Medica, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, 70124 Bari, Italy.ORCID 0000-0002-9235-8987
Laura FontanaMedical Genetics Unit, ASST Santi Paolo e Carlo, 20153 Milan, Italy.ORCID 0000-0001-9517-6997
Monica Rosa MiozzoMedical Genetics, Department of Health Sciences, Università degli Studi di Milano, 20122 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ethical challengesgenomic medicineVariants of Uncertain Significance (VUS)

Identifiers

PMID40863452
PMCPMC12387928

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.