Evidence map›Paper›PMID 40863994›Full record

ArticleNeurology international2025

Coexisting Subdural Hematoma in Cerebral Amyloid Angiopathy: A Case Series.

Matija Zupan, Lara Straus, Tomaž Velnar, Matic Bošnjak, Ulf Jensen-Kondering, Bruno Splavski, Senta Frol

Abstract readCase Reports
In one paragraph

Article in Neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matija ZupanDepartment of Vascular Neurology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Lara StrausDepartment of Vascular Neurology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Tomaž VelnarDepartment of Neurosurgery, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-6283-4348
Matic BošnjakFaculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-5536-7518
Ulf Jensen-KonderingDepartment of Neuroradiology UKSH, Campus Lübeck, 23538 Lübeck, Germany.ORCID 0000-0002-0860-4410
Bruno SplavskiDepartment of Neurosurgery, Dubrovnik General Hospital, 20000 Dubrovnik, Croatia.ORCID 0000-0002-4483-9364
Senta FrolDepartment of Vascular Neurology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0001-9494-160X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage (ICH) in elderly individuals, and it is characterized by the deposition of amyloid β protein (Aß) in the walls of small-caliber cortical and leptomeningeal vessels. The diagnostic criteria for CAA highlight its association with spontaneous lobar hemorrhage, convexity subarachnoid hemorrhage (SAH), and cortical superficial siderosis but not with subdural hematoma (SDH). This article presents a three-patient case series of CAA who experienced a lobar ICH associated with an SDH, underscoring a potentially under-recognized correlation between an acute ICH and coexistent SDH. CASE PRESENTATION: We present a case series of three patients in a single university medical center who experienced acute-onset lobar ICH with a concurrent SDH, treated with evacuation. Histopathological examination established the diagnosis of CAA in all three cases. This case series underscores a potentially under-recognized association between an acute ICH and coexistent SDH in the context of CAA.

conclusionsConsidering our findings, we emphasize the possibility that SDH may be a more frequent manifestation of CAA than previously recognized. Therefore, patients with CAA who initially present with acute SDH may be underdiagnosed, consequently leading to delayed identification and missed opportunities for proper risk assessment and management.

Indexed as

cerebral amyloid angiopathyneurosurgerysubdural hematoma

Identifiers

PMID40863994
PMCPMC12389174

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.