ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Polyphenol-Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Engineering bioactive citrate-based hydrogels for wound repair: From structure-function design to microenvironmental regulation.Bioactive materials · 2027Review
- The Versatility of Pomegranate: From Phytochemical Diversity to Antimicrobial and Translational Applications.Microorganisms · 2026Review
- Coordination-Driven Metal-Phenolic Network Complexes for Programmable Colorimetric Signal Transduction and Defined Nano-Bio Interfaces.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Design of a Gelatin/Carboxymethyl Cellulose Hydrogel Containing Myrtus Communis Extract with Anti-inflammatory Capabilities for Accelerated Wound Healing; in Vitro and in Vivo Study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Article
- Thermal-feedback modality switchable hydrogel with thermoelectric self-modulation for stage-adaptive repair of infected diabetic wound.Nature communications · 2026Article
- Versatile metal-phenolic network structure (MPNs) as advanced delivery platforms for bioactive compounds: The design principles, foundations, applications, and future perspectives.Materials today. Bio · 2026Review
- Recent Advances in Natural Extract-Based Multifunctional Gels for Food Packaging: A Review.Gels (Basel, Switzerland) · 2026Review
- Multiscale rational construction strategy for polyphenol self-assembled delivery systems: from nanoscale to microscale.Materials today. Bio · 2026Review
- Editorial for the Special Issue "Advances in Phenolic Based Complexes".Molecules (Basel, Switzerland) · 2026Article
- Composite Hydrogel Using Methacrylated Silk Fibroin and Mercaptolated Hyaluronic Acid with Encapsulating Zinc-Quercetin Nanozyme.Gels (Basel, Switzerland) · 2026Article
- Advanced metal-phenolic networks for tissue regeneration: opportunities and challenges.Journal of nanobiotechnology · 2026Review
- Plant derived tannic acid-based tissue adhesives: From mechanism to advanced design.Acta biomaterialia · 2026Review
- The Role of Polyphenols on Cognitive Function and Dementia Through Gut-Microbiota-Brain Axis Modulation: A Narrative Review.Nutrients · 2026Review
- Mitochondria-targeted nanozyme hydrogel remodels the microenvironment to enhance bone regeneration in diabetes-associated periodontitis.Journal of nanobiotechnology · 2026Article
- Tailoring the Properties and Oxidative Stability ofFoods (Basel, Switzerland) · 2026Article
- Multifunctional Biopolymer Films Based on Gelatin and Chitosan Enriched with Plant Extracts: From Functional Characterisation to Food Application and Environmental Impact.Materials (Basel, Switzerland) · 2026Article
- Article
- Carrier-free self-assembled nanomedicines from natural small molecules: advances and perspectives for disease treatment.RSC advances · 2026Review
- Plant-Based Biomaterials as Bio-Instructive Immunomodulators: Design Principles, Mechanisms, and Translational Challenges.Life (Basel, Switzerland) · 2026Review
- Polyphenol-Based Nanomedicine: Versatile Platforms for Immune Modulation and Therapeutic Delivery.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Polyphenols hold significant promise in pharmaceutical, biotechnology, and food-related applications owing to their potent free radical scavenging, antimicrobial, antitumor, and other properties. The unique chemical architecture, featuring multiple phenolic hydroxyl groups and aromatic ring systems-confers a high capacity for both non-covalent (e.g., hydrogen bonding, π-π stacking, metal ion coordination) and covalent interactions (e.g., Michael addition, Schiff base formation). These versatile interaction modes underpin the rational design and engineering of advanced composite materials with tailored functionalities. Recent advances in nanotechnology and materials science have catalyzed the integration of polyphenols with broad biomaterials, including metals, polysaccharides, and proteins, to enhance their biocompatibility, mechanical properties, and therapeutic efficacy. This review systematically explores the sources, structures, and physiological activities of polyphenols, elucidating their interaction mechanisms with different materials. Emphasis focuses on the design of polyphenol-based nanomaterials, bioactive scaffolds, and smart drug delivery platforms capable of modulating local microenvironments and orchestrating cellular responses for precision therapeutic interventions. The translational potential of these functional materials in regenerative and precision medicine is also critically examined, alongside key challenges such as stability, responsiveness, and the fine-tuning of release kinetics.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.