ArticleBiochemical genetics2026
Genetic Variants and Alteration in Transcription Factor 7-Like 2 (TCF7L2) mRNA Level in Ischemic Stroke Patients Among Bengali and Gujarati Population from India.
Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Diabetes and Hyperlipidemia are major risk factors for stroke across the world population. TCF7L2, a key regulator of the WNT signaling pathway shows genetic association with these metabolic disorders in ethnicity dependant manner. However, its role in stroke pathogenesis (if any) is not well characterized. Here, we aim to (a) investigate and correlate dysregulation of TCF7L2 expression with diabetes or hyperlipidemia-associated Ischemic Stroke (b) identify genetic risk variants in the TCF7L2 gene, and (c) establish correlations between TCF7L2 mRNA levels and biochemical parameters. Based on radiological findings for Ischemic Stroke, a total of 50 unrelated subjects were recruited with diverse biochemical parameters for TCF7L2 mRNA expression study in PBMC, followed by correlation with fasting blood sugar and lipid profile. Furthermore, mutation screening (31 Cases and 30 Controls) and genetic association studies (rs7901695 & rs7903146) were performed among 326 cases and 258 controls from two different ethnic population of India. In our study, a significant downregulation of TCF7L2 transcript was observed between stroke cases and controls as major finding. Furthermore, stratification of stroke cases, according to their blood lipid and glucose level revealed a lower quantity of TCF7L2 transcript in hyperlipidemia stroke cases than non-hyperlipidemia subjects. However, no such association against diabetic status was observed. A simultaneous finding showing negative correlation of gene expression with total blood cholesterol level (P = 0.0187; r = - 0.4012) but not for diabetes, thus suggests TCF7L2 mediated altered lipid metabolism as a risk for stroke pathogenesis. On the other hand, allelic (P = 0.0207) and genotypic (P = 0.0002) association of functional variants like rs7901695 variants [P = 0.0207] among the majorly Bengali population of Kolkata and rs7903146 [P = 0.0164] among the Gujarati cohort was observed, respectively. Thus, on basis of our findings, genotyping of TCF7L2 variants or quantification of transcript, consumption of low-fat diet may be recommended to hyperlipidemia individuals for risk prediction and preventive treatment regimen, respectively.
Indexed as
Identifiers
40864349What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.