ReviewMolecular and cellular biochemistry2025
Chronic stress, gut microbiota, and immunity: interconnections and implications for health.
Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut microbiota alterations associated with anxiety and depression in inflammatory bowel disease: a systematic review of prospective cohorts and randomized trials.Frontiers in microbiology · 2026Pooled it
- Microbiome-metabolite signaling networks in gastrointestinal disease: systems biology, network rewiring, and precision therapeutics.Archives of microbiology · 2026Review
- Targeting the gut-brain axis: microbial interventions for neurological disorders.Metabolic brain disease · 2026Review
- Diet, gut microbiota, and the gut-brain axis: mechanistic interactions and therapeutic implications in neuropsychiatric disorders.Frontiers in cellular and infection microbiology · 2026Review
- Dynamic impacts of COVID-19 on immune cells and inflammatory indicators in Chinese medical health workers: a retrospective longitudinal study.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Psychological stress influences the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal -medullary (SAM) axes which directly impact the immune system. Stress not only affects hematopoietic stem cell activity but also increases the circulating levels of inflammatory cells, thereby potentially exacerbating pathogenic conditions. Moreover, stress affects hormone release, inflammation, and autonomic changes, which can modify the composition of the gut microbiota and indirectly alter the immune system. This review aims to summarize the research that demonstrates the relationships among stress, the gut microbiota, and hematopoiesis to increase our understanding of the intricate connections among them, while also highlighting the bidirectional influences among chronic diseases, systemic inflammation, and stress.
Indexed as
Identifiers
40864384What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.