ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Biomechanical implications of mass loading in a swine model of acute hypoxemic respiratory failure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Obesity: biomechanical implications for mechanical ventilation.Critical care (London, England) · 2026Review
- Sex-related differences in lung injury distribution and outcomes in COVID-19 acute respiratory failure: insights from the CT-COVID19 multicenter study group.Intensive care medicine experimental · 2026Article
- Biomechanical Phenotyping of Forced Expiration for Precision Pulmonary Rehabilitation: A Machine Learning Approach to Identify Structural and Kinetic Drivers.Advances in respiratory medicine · 2026Article
- The impact of metabolic syndrome on regional ventilation and perfusion in ARDS: an observational cohort study using electrical impedance tomography.Intensive care medicine experimental · 2026Article
- Expert recommendations for setting and adjusting airway pressure release ventilation based on clinical experience and basic science evidence.Frontiers in medicine · 2026Article
- A clinical guide to non-invasive respiratory support in acute respiratory failure: ventilation settings, technical optimization and clinical indications.Critical care (London, England) · 2025Review
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Funding
Abstract
In obesity, excess weight of the chest and abdomen (mass loading) decreases lung volume and can worsen acute hypoxemic respiratory failure (AHRF). We investigated whether positive end-expiratory pressure (PEEP) fully reverses the effects of mass loading on lung volume and respiratory mechanics in an AHRF swine model. Eighteen Yorkshire pigs were studied: six healthy, eight pre- and postinjury, and four postinjury only. We randomly tested three mass loading conditions: without mass loading, with abdominal loading (6 kg weight), and with combined abdominal and chest mass loading (12 kg total weight). We performed a recruitment maneuver in each condition, followed by a decremental PEEP trial, and identified the best-PEEP as that with the greatest respiratory system compliance (
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