ArticlePsychiatry and clinical psychopharmacology2025
Brief Manual for Multi-Modal Motion-Assisted Memory Desensitization and Reconsolidation Therapy for the Treatment of Post-traumatic Stress Disorder.
Article in Psychiatry and clinical psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Walk and Talk: A Randomized Controlled Trial of Multi-Modal Motion-Assisted Memory Desensitization and Reconsolidation Therapy versus Treatment as Usual for Veterans and First Responders with Posttraumatic Stress Disorder.Psychotherapy and psychosomatics · 2026Trial
- 3MDR: From rehabilitation technology to a transformative trauma therapy for posttraumatic stress disorder.Journal of military, veteran and family health · 2026Article
- From facing fears to experimental frontiers: immersive cinematic virtual reality environments as a catalyst for innovation in behavioral neuroscience.Frontiers in psychiatry · 2026Article
- Case Report: Multi-modal motion-assisted memory desensitization and reconsolidation for traumatic grief (3MDR-TG).Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multi-Modal Motion-Assisted Memory Desensitization and Reconsolidation (3MDR) is an innovative exposure-based immersive psychotherapeutic intervention for the treatment of post-traumatic conditions such as post-traumatic stress disorder (PTSD) and other related trauma disorders. This manual reviews the theoretical foundations, protocol, and key therapeutic processes of 3MDR, emphasizing its applicability across clinical and research settings. Developed to overcome barriers to traditional trauma-focused psychotherapies, 3MDR combines immersive virtual reality (VR), motion-assisted engagement, and personalized trauma cues to facilitate memory processing and emotional reconsolidation. The 3MDR integrates VR technology, treadmill-assisted movement, and dual-attention tasks to create a dynamic and interactive therapeutic environment. The intervention consists of 3 phases: pre-platform preparation, platform exposure, and post-platform reconsolidation, allowing for structured and progressive trauma processing. Patients engage with self-selected trauma-related images and music, guided by a therapist, to confront distressing memories, reduce avoidance, and foster emotional regulation. The dual-attention task and affect labeling enhance cognitive and emotional integration, while walking promotes a sense of agency and movement through trauma. Clinical research demonstrates 3MDR's efficacy in reducing PTSD symptoms, depression, and anxiety, with high acceptability and low dropout rates among military personnel, veterans, and first responders. Emerging evidence suggests its adaptability for diverse populations, including civilians and individuals with complex trauma histories. This manual provides detailed guidance for implementing 3MDR, underscoring the importance of therapist training, ethical considerations, and continued research to optimize its application and expand access to this promising intervention. This manual should be seen as a companion and not a replacement for training.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.