Evidence map›Paper›PMID 40866353›Full record

ArticleNature communications2025

Interaction of genetic variants activates latent metabolic pathways in yeast.

Srijith Sasikumar, Shannara Taylor Parkins, Suresh Sudarsan, Himanshu Sinha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Srijith SasikumarSystems Genetics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.ORCID http://orcid.org/0009-0001-9244-4359
Shannara Taylor ParkinsThe Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Suresh SudarsanThe Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Himanshu SinhaSystems Genetics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India. sinha@iitm.ac.in.ORCID http://orcid.org/0000-0001-7031-0491

Funding

Indian Institute of Technology Madras (IITM) BIO/1819/304/ALUM/KARHIndian Institute of Technology Madras (IITM) SB/2021/0841/BT/MHRD/08752Novo Nordisk Fonden (Novo Nordisk Foundation) NNF20CC0035580
6 · The paper itself

Abstract

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways and if such pathways can be targeted to modulate phenotypic outcomes. The model organism Saccharomyces cerevisiae was used to dissect how two causal SNPs, MKT1

Indexed as

Metabolic Networks and PathwaysPolymorphism, Single NucleotideSaccharomyces cerevisiaeArginineGene Expression Regulation, FungalMetabolomicsMitochondriaPhenotypeProteomicsRibosomesSaccharomyces cerevisiae ProteinsSpores, FungalArginineSaccharomyces cerevisiae Proteins

Identifiers

PMID40866353
PMCPMC12391433

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.