Evidence map›Paper›PMID 40866372›Full record

ArticleScientific reports2025

Metabolomic profile associated with preeclampsia and its severity: a case-control study in Colombian pregnant women.

Claudia C Colmenares-Mejia, Paula K Bautista-Nino, Doris C Quintero-Lesmes, Carlos Riaño, Jose Maria Satizabal, Jie Hu, Kathryn J Gray, Norma C Serrano

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudia C Colmenares-MejiaBasic Science School, Health Faculty, Universidad del Valle, Cali, Colombia. claudiacolmenares@fcv.org.ORCID http://orcid.org/0000-0003-1847-4282
Paula K Bautista-NinoResearch Centre, Fundación Cardiovascular de Colombia - (FCV), Centro Internacional de Especialistas, Valle de Menzuly Km 7, Piedecuesta, Santander Bucaramanga, Colombia.ORCID http://orcid.org/0000-0002-1206-324X
Doris C Quintero-LesmesResearch Centre, Fundación Cardiovascular de Colombia - (FCV), Centro Internacional de Especialistas, Valle de Menzuly Km 7, Piedecuesta, Santander Bucaramanga, Colombia.ORCID http://orcid.org/0000-0001-8875-0110
Carlos RiañoObstetrics and Gynecology Chief Department, Fundación Cardiovascular de Colombia, Floridablanca, Colombia.
Jose Maria SatizabalBasic Science School, Health Faculty, Universidad del Valle, Cali, Colombia.ORCID http://orcid.org/0000-0002-0317-6664
Jie HuCenter for Genomic Medicine and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8282-4895
Kathryn J GrayDepartment of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3541-3724
Norma C SerranoResearch Centre, Fundación Cardiovascular de Colombia - (FCV), Centro Internacional de Especialistas, Valle de Menzuly Km 7, Piedecuesta, Santander Bucaramanga, Colombia.ORCID http://orcid.org/0000-0003-3532-2002

Funding

Integrative omics of preeclampsia in TOPMED and maternal cardiovascular healthR01HL163234 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA · 2022 to 2025
$2.8M
Precision medicine approaches to understand and prevent stillbirthR01HD117802 · NICHD · UNIVERSITY OF WASHINGTON · PI Kathryn Johnson Gray · 2025 to 2026
$1.3M
Signatures of dysfunctional mitochondrial fatty acid oxidation that predispose to early-onset preeclampsiaK08HL146963 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GRAY, KATHRYN JOHNSON · 2019 to 2023
$940k
Clinical and functional follow-up of maternal and fetal preeclampsia genetic risk lociR03HL162756 · NHLBI · UNIVERSITY OF WASHINGTON · PI GRAY, KATHRYN JOHNSON · 2022 to 2023
$168k
Longitudinal metabolic profiling throughout gestation in the plasma and urine of women who develop early-onset preeclampsiaF32HD086948 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI GRAY, KATHRYN JOHNSON · 2016 to 2017
$76k
Ministerio de Ciencia, Tecnología e Innovación ID 404-2020 656684468096NHLBI NIH HHS HL146963NHLBI NIH HHS K08 HL146963NHLBI NIH HHS R01 HL163234NHLBI NIH HHS R03 HL162756NICHD NIH HHS F32 HD086948NICHD NIH HHS R01 HD117802
6 · The paper itself

Abstract

Extra-large HDL molecules (average diameter 14.3 nm) were inversely associated with preeclampsia. Additionally, extremely (particle diameters from 75 nm upwards) and very large (average diameter 64 nm) VLDL metabolites were associated with an increased the risk of preeclampsia. These findings provide evidence of molecules of interest for establishing risk or developing potential therapeutic targets" to "Specifically, extra-large HDL molecules (average diameter 14.3 nm) were inversely associated with preeclampsia, whereas extremely large (≥75 nm) and very large (average diameter 64 nm) VLDL metabolites were associated with an increased risk. These findings highlight distinct lipoprotein-related metabolic signatures linked to preeclampsia and suggest potential targets for risk assessment and therapeutic intervention.

Indexed as

MetabolomeMetabolomicsPre-EclampsiaAdultCase-Control StudiesColombiaFemaleHumansLipoproteins, HDLLipoproteins, VLDLPregnancyLipoproteins, HDLLipoproteins, VLDLBiomarkersHELLP syndromeMetabolomicsPreeclampsia

Identifiers

PMID40866372
PMCPMC12391528

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.