Evidence map›Paper›PMID 40866493›Full record

ArticleScientific reports2025

Gut microbiota profiles are associated with different spontaneous cortical activity in healthy older people.

J Ignacio Serrano, Silvia Cruz-Gil, Cristina M Fernández, Lara P Fernández, Ana Sobrino-Santos, Isabel Espinosa-Salinas, Carolina Maestre, María-Jesús Latasa, Manuel Cebrián, Ricardo Ramos-Ruiz and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

J Ignacio SerranoComputational Models of Intelligence group, Center for Automation and Robotics (CAR, CSIC-UPM), Consejo Superior de Investigaciones Científicas (CSIC), Ctra. Campo Real km 0.200, 28500, Arganda del Rey, Spain. jignacio.serrano@csic.es.
Silvia Cruz-GilMolecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain.
Cristina M FernándezMolecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain.
Lara P FernándezMolecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain.
Ana Sobrino-SantosComputational Models of Intelligence group, Center for Automation and Robotics (CAR, CSIC-UPM), Consejo Superior de Investigaciones Científicas (CSIC), Ctra. Campo Real km 0.200, 28500, Arganda del Rey, Spain.
Isabel Espinosa-SalinasMolecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain.
Carolina MaestreCentro Nacional de Investigaciones Oncológicas (CNIO), C. de Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029, Madrid, Spain.
María-Jesús LatasaMolecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain.
Manuel CebriánComputational Models of Intelligence group, Center for Automation and Robotics (CAR, CSIC-UPM), Consejo Superior de Investigaciones Científicas (CSIC), Ctra. Campo Real km 0.200, 28500, Arganda del Rey, Spain.
Ricardo Ramos-RuizMolecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain.
Ana Ramírez de Molina *Molecular Oncology and Nutritional Genomics of Cancer Group, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain.
M Dolores Del Castillo *Computational Models of Intelligence group, Center for Automation and Robotics (CAR, CSIC-UPM), Consejo Superior de Investigaciones Científicas (CSIC), Ctra. Campo Real km 0.200, 28500, Arganda del Rey, Spain.

Funding

Consejo Superior de Investigaciones Científicas PIE202350E170MICIU/AEI/ 10.13039/501100011033 PID2022-138295OB-I00MICIU/AEI/ 10.13039/501100011033, FEDER/UE RTC2019-007294-1Regional Government of Community of Madrid NutriSION-CM Y2020/BIO-6350Spanish Ministry of Science, Innovation and University, Spanish State Research Agency PID2023-150271NB-C21Spanish Ministry of Science, Innovation and University, Spanish State Research Agency PID2023-150271NB-C22
6 · The paper itself

Abstract

It has been shown that the gut and the brain are linked through a multimodal, bidirectional pathway called the gut-brain axis. In the gut-to-brain way, the gut microbiota has been shown to be the main regulator. In clinical practice, evidence of microbiota and brain interactions comes from the association of gut microbiota alterations with neurological and psychiatric conditions. However, until now, it remains unknown how the gut microbiota influences brain activity. In this paper, we show that different microbiota profiles from healthy older people are associated with different spontaneous activity in medial posterior cortical areas. These areas are associated with memory, language, and emotion processing abilities. Therefore, the results obtained provide evidence that non-pathological gut microbiota profiles are correlated to spontaneous cortical activity associated with cognitive functions that typically deteriorate with age. This implies that early nutritional interventions that modify microbiota composition could help delay or ameliorate natural age-related cognitive decline.

Indexed as

BrainCerebral CortexGastrointestinal MicrobiomeAgedAged, 80 and overAgingCognitionFemaleHumansMagnetic Resonance ImagingMaleMemoryMiddle AgedEEG source densityGut-brain axisGut microbiota profilesHealthy older population.Spontaneous cortical activity

Identifiers

PMID40866493
PMCPMC12391352

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.