ArticleScientific reports2025
Biocompatibility and antioxidant effects of hydroxyapatite-quercetin composites: in vitro and in ovo studies.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Single-cell mapping of homocysteine-induced perturbations in avian embryogenesis using LMO and BD rhapsody transcriptomics.iScience · 2026Article
- Synergistic antioxidant and anti-inflammatory scaffold based on ascorbic acid-enriched hydroxyapatite-PEG-ZnO composite from natural bone waste.Journal of materials science. Materials in medicine · 2026Article
- Oxidative homeostasis and survival instincts of chicken egg, embryo and adult.Poultry science · 2026Review
- Macrophage Membrane-Cloaked, ROS-Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome.Advanced healthcare materials · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxyapatite (HaP) is a biomaterial valued for its biocompatibility and osteoconductive properties, making it suitable for implantology and tissue engineering. The natural flavonoid quercetin (Q) exhibits potent antioxidant and anti-inflammatory effects that support wound healing and reduce oxidative stress. This study assessed the combined impact of HaP and Q on fibroblast viability, oxidative stress markers, and cell migration. The in ovo model evaluated systemic effects via morphometric parameters and oxidative stress in embryonic liver tissue.Results show that Q significantly decreased oxidative stress by increasing antioxidant enzyme activity and reducing intracellular ROS levels in fibroblasts and embryonic liver (p < 0.05). HaP alone induced a mild pro-oxidant response, but its combination with Q (QHaP) led to a marked reduction in oxidative stress markers, indicating a protective synergistic effect. Scratch assay revealed that Q and QHaP enhanced fibroblast migration at all concentrations, with HaP
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