Evidence map›Paper›PMID 40866541›Full record

ArticleMolecular psychiatry2026

Multilevel white matter degeneration associated cognitive dysfunction in mild cognitive impairment.

Yu Chen, Tiantian Liu, Li-Zhi Cao, Li Wang, Shintaro Funahashi, Xiaoying Tang, Jinglong Wu, Wei Meng, Jian Zhang, Tianyi Yan and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu ChenSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China.ORCID http://orcid.org/0009-0001-2483-6115
Tiantian LiuSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China. tiantian2bit@bit.edu.cn.ORCID http://orcid.org/0000-0001-5384-0642
Li-Zhi CaoSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China.
Li WangSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China.ORCID http://orcid.org/0000-0001-9819-9051
Shintaro FunahashiAdvanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Haidian District, Beijing, China.
Xiaoying TangSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China.
Jinglong WuSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China.
Wei MengDepartment of Radiology, Harbin Medical University, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Jian ZhangSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China. zhangjian2023@bit.edu.cn.
Tianyi YanSchool of Medical Technology, Beijing Institute of Technology, Haidian District, Beijing, China. yantianyi@bit.edu.cn.ORCID http://orcid.org/0000-0002-2674-4134
Alzheimer’s Disease Neuroimaging Initiative

Funding

China Postdoctoral Science Foundation 2023TQ0027China Postdoctoral Science Foundation 2024M754099National Natural Science Foundation of China (National Science Foundation of China) 62306035National Natural Science Foundation of China (National Science Foundation of China) 62336002National Natural Science Foundation of China (National Science Foundation of China) 62373056National Natural Science Foundation of China (National Science Foundation of China) 62406025National Natural Science Foundation of China (National Science Foundation of China) 82071912Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) IS23114Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) IS23115
6 · The paper itself

Abstract

Mild cognitive impairment (MCI), the prodromal stage of dementia, is characterized by cognitive dysfunction and white matter (WM) disruption. To investigate the WM microstructure degeneration at different scales in MCI, the orientation-sensitive fixel-based analysis was performed with fixelwise, fiberwise fiber-specific measures in 50 patients with MCI compared to 75 healthy controls. Moreover, to clarify the patterns of the organization operating at different scales in MCI, the potential mediated effects of structural connectome in networkwise on the associations between microstructure alterations of 24 anatomical tracts and cognitive dysfunction were analyzed. Compared to healthy controls, specific tracts were widely disrupted in fiberwise in patients with MCI, represented by the decrease of fiber density and cross-section in most commissural fibers and many association fibers, which was consistent with previous findings. The associations between WM microstructural degeneration and multi-domain cognitive dysfunction were also observed. Interestingly, the structural connectome between visual and salience networks played a potential mediating role in the relationship between disruption of WM microstructure and worse language performance, and we also found a similar situation in the memory domain. The present study provides mechanistic insight into the relationship between microstructure damage and cognitive dysfunction in prodromal dementia under a multilevel WM hierarchy.

Indexed as

Cognitive DysfunctionWhite MatterAgedBrainConnectomeDementiaDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Tests

Identifiers

PMID40866541

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.