ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Relationship between symptom burden and benefit finding in patients with gastrointestinal cancers undergoing chemotherapy: the chain-mediating role of comprehensive needs and communication pattern.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Beyond drug toxicity: the hidden burden of financial toxicity in hepatocellular carcinoma.Journal of gastrointestinal oncology · 2026Article
- Influential factors of benefit finding in hemodialysis patients: a qualitative study using the social-ecological model.BMC nephrology · 2026Article
- Latent Profiles of Illness Cognition and Their Associations with Postoperative Symptom Burden Among Patients with Esophageal Cancer After Minimally Invasive Esophagectomy: A Multicentre Cross-Sectional Study.Patient preference and adherence · 2026Article
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Abstract
backgroundPatients with gastrointestinal (GI) cancer undergoing chemotherapy frequently exhibit heterogeneous symptom burden, while psychological adaptation may exert differential impacts on benefit finding.
objectivesTo explore the relationship between symptom burden and benefit finding in GI cancer patients, and to determine whether comprehensive needs and communication pattern play a mediating role in this relationship.
methodsThis was a cross-sectional study. The study employed a convenience sampling method to recruit 221 eligible GI cancer patients from the digestive oncology ward of a Tertiary Grade-A Hospital in Qingdao, China between September 2024 and January 2025. Assessments were conducted using the M.D. Anderson Symptom Inventory (MDASI), Comprehensive Needs Assessment Tool in cancer for patient (CNAT), Patient Communication Pattern Scale (PCPS), and the Benefit Finding Scale (BFS). The Cronbach's α coefficients of all scales are all above 0.8, and they are applicable to the Chinese population. The study variables are all continuous variables; data analysis was conducted using descriptive statistics, Pearson correlation, linear regression, and the PROCESS macro.
resultsPearson correlation analysis showed that in GI cancer patient, there was a significant positive correlation between symptom burden and comprehensive needs (r = 0.512, p < 0.001), a significant negative correlation with communication patterns (r = - 0.473, p < 0.001) and benefit finding (r = - 0.520, p < 0.001). Furthermore, the mediation analysis revealed that the total effect of symptom burden on benefit finding was - 0.351. The comprehensive needs and communication pattern served as partial mediators in the influence of symptom burden on the disease benefit. The mediating effects are 33.05% and 15.38%, respectively. The chained mediation effect was - 0.034, representing 9.69% of the total effect.
conclusionThe comprehensive needs and communication pattern play a chain-mediating role in the relationship between symptom burden and benefit finding. Timely identification of patients' comprehensive needs and optimization of communication pattern undergoing chemotherapy may serve as important targets for psycho-social interventions. These findings suggest that implementing dynamic assessments to monitor evolving patient needs can facilitate the development of precision communication interventions, to mitigate the negative impact of symptom burden on benefit finding.
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