ArticleJournal of ovarian research2025
Deciphering the interplay between oxidative stress and inflammation in polycystic ovary syndrome: outcome of a case-control study.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Redox biology in PCOS: Biomarkers, mechanistic networks, and targeted interventions (Review).International journal of molecular medicine · 2026Review
- Epigenetic regulation of ovarian steroidogenesis in PCOS: HDAC inhibitors and short-chain fatty acids.Molecular biology reports · 2026Review
- Therapeutic potential of natural products in polycystic ovary syndrome.Molecular biology reports · 2026Review
- Molecular analysis of FSHR rs6166 polymorphism and oxidative stress parameters in women with polycystic ovary syndrome.Molecular biology reports · 2026Article
- Insulin resistance, inflammation, oxidative stress and dysregulated WNT/β-Catenin signaling in polycystic ovary syndrome: A review.Molecular biology reports · 2026Review
- Redox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails?Frontiers in endocrinology · 2026Review
- Oxidative Stress-Telomere Axis in IVF: Molecular Mechanisms, Biomarkers, and Clinical Translation.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
contextLow-grade inflammation (LGI) and oxidative stress (OS) are key features in women with polycystic ovary syndrome (PCOS), but the interplay between these factors and genetic makeup in PCOS pathogenesis remains unclear.
objectiveThis study investigated OS indicators, sub-inflammation, and their correlations in women with hyperandrogenic and insulin-resistant PCOS, examining the relationship with WNT3 gene expression. METHODOLOGY: A case-control study included 270 age-matched women (135 with PCOS and 135 healthy controls). Participants underwent detailed medical and clinical examinations, followed by biochemical, hormonal, inflammation, and OS and WNT3 gene expression assessments.
resultsSerum levels of inflammatory markers TNFα (24.98 ± 3.07vs.20.07 ± 6.83), IL6 (4.08 ± 0.90vs.3.09 ± 0.90), and IL1β (12.03 ± 2.81vs.8.61 ± 4.02) were significantly higher in women with PCOS compared to controls (p < 0.001). Total oxidant stress (TOS) was significantly elevated in PCOS cases (6.16 ± 0.46vs.1.82 ± 0.71), whereas antioxidant enzymes Superoxide Dismutase (SOD) and catalase were higher in controls (p < 0.001). Waist circumference positively correlated with IL1β, LDL, and triglycerides, and negatively with HOMA, QUICKI, HDL, and TNFα (p < 0.05). TNFα positively correlated with IL1β (r = 0.26, p < 0.0001). TOS correlated positively with HOMA, TNFα, IL1β, and LDL, and negatively with SOD, catalase, and testosterone (p < 0.0001). Catalase positively correlated with QUICKI and SOD, and negatively with HOMA and TOS (p < 0.0001). WNT3 gene mRNA expression was undetectable in peripheral blood samples from both PCOS cases and controls.
conclusionThe study underscores the significant role of OS and sub-inflammation in PCOS pathophysiology. However, WNT3 gene expression in peripheral blood was undetectable; suggesting further research with different tissues or more sensitive methods is needed.
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