ReviewStem cell research & therapy2025
Optimal transplantation strategies for stem cell treatment in premature ovarian failure: a network meta-analysis.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Current Status of Animal Models for Premature Ovarian Insufficiency: Similarities to Clinical Manifestations and Therapeutic Applications.Tissue engineering and regenerative medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe incidence of POF has increasingly affected younger individuals in recent years, and stem cell therapy has gradually been incorporated in clinical practice. Given the wide variety of stem cell sources, there are inherent differences in their biological characteristics and functions. This article compares the efficacy of stem cells from different sources in the treatment of premature ovarian failure in an animal model, and provides a basis for their clinical application.
methodsA search was conducted for studies on stem cell therapy for POF animal models in PubMed, Cochrane Library, CBM, EMbase, CNKI, Wanfang, VIP, and the time limit for searching was from the date of the establishment of the respective databases to 2024-12-31. After screening the literature, two researchers independently extracted and analyzed the data. The quality of the included studies was assessed using the SYRCLE Animal Experimentation Risk of Bias Assessment Scale. The main outcome measures included estradiol, follicle-stimulating hormone, luteinising hormone, and the number of follicles at each level. After assessing the risk of bias in the included studies, a network meta-analysis, plotting, and tabulation were performed using Stata 15.0 software.
resultsThirty-three animal studies involving 877 experimental mice were finally included. The overall quality of the literature was considered medium. The results suggest that four stem cell therapies--UC-MSCs, AD-MSCs, HuMenSCs and OGSCs, may be the four most efficacious in the treatment of POF; and UC-MSCs may show superior therapeutic advantage in increasing the number of follicles. When comparing transplantation routes, Tail Vein Injection and Intraovarian Injection may have higher efficacy compared to other routes of administration.
conclusionsThis study systematically explores the therapeutic strategies for POF treatment using stem cell therapy. Further research is necessary to identify the optimal transplantation strategy and to advance both animal experiments and clinical research by improving and standardizing the design, implementation, and reporting of such studies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.