Evidence map›Paper›PMID 40867532›Full record

ArticleBiomolecules2025

Melatonin as an Alleviator in Decabromodiphenyl Ether-Induced Aberrant Hippocampal Neurogenesis and Synaptogenesis: The Role of Wnt7a.

Jinghua Shen, Lu Gao, Jingjing Gao, Licong Wang, Dongying Yan, Ying Wang, Jia Meng, Hong Li, Dawei Chen, Jie Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinghua ShenDepartment of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou 121001, China.ORCID 0009-0005-2529-7730
Lu GaoDepartment of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou 121001, China.ORCID 0009-0001-3355-7265
Jingjing GaoDepartment of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Licong WangSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Dongying YanDepartment of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Ying WangDepartment of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Jia MengDepartment of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Hong LiSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Dawei ChenSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.ORCID 0000-0002-4015-2557
Jie WuDepartment of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou 121001, China.ORCID 0000-0001-5139-9486

Funding

Foundation of Liaoning Provincial Education Administration LJKQZ2021149Natural Science Foundation of Liaoning Province 2023-MS-310, 2019-BS-098
6 · The paper itself

Abstract

Developmental exposure to polybrominated diphenyl ethers (PBDEs), which are commonly used as flame retardants, results in irreversible cognitive impairments. Postnatal hippocampal neurogenesis, which occurs in the subgranular zone (SGZ) of the dentate gyrus, is critical for neuronal circuits and plasticity. Wnt7a-Frizzled5 (FZD5) is essential for both neurogenesis and synapse formation; moreover, Wnt signaling participates in PBDE neurotoxicity and also contributes to the neuroprotective effects of melatonin. Therefore, we investigated the impacts of perinatal decabromodiphenyl ether (BDE-209) exposure on hippocampal neurogenesis and synaptogenesis in juvenile rats through BrdU injection and Golgi staining, as well as the alleviation of melatonin pretreatment. Additionally, we identified the structural basis of Wnt7a and two compounds via molecular docking. The hippocampal neural progenitor pool (Sox2+BrdU+ and Sox2+GFAP+cells), immature neurons (DCX+) differentiated from neuroblasts, and the survival of mature neurons (NeuN+) in the dentate gyrus were inhibited. Moreover, in BDE-209-exposed offspring rats, it was observed that dendritic branching and spine density were reduced, alongside the long-lasting suppression of the Wnt7a-FZD5/β-catenin pathway and targeted genes (

Indexed as

Halogenated Diphenyl EthersHippocampusMelatoninNeurogenesisSynapsesWnt ProteinsAnimalsDoublecortin ProteinFemaleMaleMolecular Docking SimulationPregnancyProto-Oncogene ProteinsRatsRats, Sprague-DawleyDcx protein, ratdecabromobiphenyl etherDoublecortin ProteinHalogenated Diphenyl EthersMelatoninProto-Oncogene ProteinsWnt7a protein, ratWnt Proteinsdecabromodiphenyl ethermelatoninneurogenesissynaptogenesisWnt7a

Identifiers

PMID40867532
PMCPMC12383937

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.