Evidence map›Paper›PMID 40867541›Full record

ReviewBiomolecules2025

CD4/CD8-p56

Andres Oroya, Christopher E Rudd

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andres OroyaDépartement de Médicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.ORCID 0000-0002-9012-3041
Christopher E RuddDépartement de Médicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.

Funding

T Cell Memory in Organ TransplantationR01AI049466 · NIAID · YALE UNIVERSITY · PI LAKKIS, FADI G. · 2001 to 2024
$7.5M
Canadian Institutes of Health Research Foundation 159912NIAID NIH HHS R01 AI049466NIH HHS 1C06TW049466-20
6 · The paper itself

Abstract

T-cells constitute an essential component of the adaptive immune response, mount a protective response against foreign pathogens and are important regulators of anti-tumor immunotherapy. In this context, the activation of T-cells and chimeric antigen receptor (CAR)-expressing T-cells is orchestrated by various signaling pathways, involving the initiation of a protein tyrosine phosphorylation cascade. For T-cells, this involves initiation of the phosphorylation cascade via

Indexed as

CD4 AntigensCD8 AntigensImmunotherapyLymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-CellSignal TransductionAnimalsHumansLymphocyte ActivationPhosphorylationReceptors, Chimeric AntigenCD4 AntigensCD8 AntigensLymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-CellReceptors, Chimeric Antigencancer immunotherapyCAR T-cellp56lckprotein phosphorylationsignal transductionT-cell receptor

Identifiers

PMID40867541
PMCPMC12383362

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.