Evidence mapPaperPMID 40867608Full record

ArticleBiomolecules2025

Neuronal Count, Brain Injury, and Sustained Cognitive Function in 5×FAD Alzheimer's Disease Mice Fed DHA-Enriched Diets.

Cristina de Mello-Sampayo, Mafalda Soares Pádua, Maria Rosário Silva, Maria Lourenço, Rui M A Pinto, Sandra Carvalho, Jorge Correia, Cátia F Martins, Romina Gomes, Ana Gomes-Bispo and 4 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cristina de Mello-SampayoiMED.UL, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisboa, Portugal.
Mafalda Soares PáduaCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.ORCID 0009-0009-5464-9829
Maria Rosário SilvaCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.
Maria LourençoiMED.UL, Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisboa, Portugal.ORCID 0000-0002-1661-239X
Rui M A PintoFaculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisboa, Portugal.ORCID 0000-0002-1667-7871
Sandra CarvalhoCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.
Jorge CorreiaCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.ORCID 0000-0002-1909-4540
Cátia F MartinsLEAF-Linking Landscape, Environment, Agriculture and Food Research Center, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal.ORCID 0000-0002-1017-3269
Romina GomesDivisão de Aquacultura, Valorização e Bioprospeção (DivAV), Instituto Português do Mar e da Atmosfera (IPMA, I.P.), Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal.
Ana Gomes-BispoDivisão de Aquacultura, Valorização e Bioprospeção (DivAV), Instituto Português do Mar e da Atmosfera (IPMA, I.P.), Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal.ORCID 0000-0001-5354-2397
Cláudia AfonsoDivisão de Aquacultura, Valorização e Bioprospeção (DivAV), Instituto Português do Mar e da Atmosfera (IPMA, I.P.), Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal.ORCID 0000-0002-5717-818X
Carlos CardosoDivisão de Aquacultura, Valorização e Bioprospeção (DivAV), Instituto Português do Mar e da Atmosfera (IPMA, I.P.), Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal.ORCID 0000-0001-7273-0676
Narcisa BandarraDivisão de Aquacultura, Valorização e Bioprospeção (DivAV), Instituto Português do Mar e da Atmosfera (IPMA, I.P.), Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal.
Paula A LopesCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.ORCID 0000-0002-6755-4572

Funding

Fundação para a Ciência e a Tecnologia, Lisboa, Portugal FCT.2022.08133.PTDC
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia, affecting over 50 million people globally. Since 1906, efforts to understand this neurodegenerative disease and to develop effective treatments have continued to this day. Recognizing docosahexaenoic acid (DHA, 22:6n-3) as a safe, inexpensive and vital nutrient for brain health and cognitive protection due to its key role in brain development and function, this study explores novel, sustainable non-fish sources as potential dietary supplements to prevent or mitigate AD, within a blue biotechnology framework. Forty 5×FAD male mice, five weeks old, were allocated to five body weight-matched dietary groups (

Indexed as

Alzheimer DiseaseBrain InjuriesCognitionDocosahexaenoic AcidsNeuronsAnimalsBrainDietary SupplementsDisease Models, AnimalFish OilsMaleMiceDocosahexaenoic AcidsFish Oils5×FAD transgenic miceAlzheimer’s diseasebrain immunohistochemistrycognitive declineDHA-enriched dietsfatty acid profileneuronal count

Identifiers

PMID40867608
PMCPMC12383990

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.