Evidence map›Paper›PMID 40867609›Full record

ReviewBiomolecules2025

Effect of Nematodes-Bacteria Complex Metabolites on Cancer and Tumor Progression.

Aisa Bahar, Malihe Parsa Sefat, Meisam Khazaei, Hamed Tahmasebi, Valentyn Oksenych

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aisa BaharSchool of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, Iran.ORCID 0000-0003-0822-6728
Malihe Parsa SefatSchool of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, Iran.ORCID 0000-0001-5852-0912
Meisam KhazaeiSchool of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, Iran.ORCID 0000-0003-1517-4225
Hamed TahmasebiSchool of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, Iran.ORCID 0000-0002-9257-4479
Valentyn OksenychFaculty of Medicine, University of Bergen, 5020 Bergen, Norway.ORCID 0000-0002-5088-3791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helminths that inhabit the gastrointestinal (GI) tract represent some of the most significant infectious agents impacting health. The interaction between the human microbiota, GI helminths, and their host occurs through multiple complex pathways, altering the host's immune system and the dynamics of the commensal gut microbiota (GM). These interactions also largely influence a balanced state of homeostasis and health promotion and robustly activate the immune system, facilitating tumor eradication and mitigating the challenges of drug resistance. Furthermore, incorporating microbial metabolites into radiotherapy and chemotherapy reduces the intense adverse effects of these treatments while enhancing their overall effectiveness. The interplay between GM and helminths, as well as their metabolites, significantly impacts the development, prognosis, and treatment of cancer. The interaction mechanisms between GI helminths and the GM are not fully elucidated. Thus, understanding a beneficial biological relationship can reveal hidden mechanisms for controlling and inhibiting cancer pathways in humans by providing insights into cellular processes and potential therapeutic targets. This knowledge can be applied to develop more effective cancer treatments. This review outlines the existing research on GM metabolites in cancer, intending to offer innovative pathways for future cancer treatment.

Indexed as

BacteriaGastrointestinal MicrobiomeNematodaNeoplasmsAnimalsDisease ProgressionHumansapoptosiscancergastrointestinal helminthsgastrointestinal microbiotagut microbiota

Identifiers

PMID40867609
PMCPMC12384441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.