Evidence map›Paper›PMID 40867616›Full record

ArticleBiomolecules2025

Glycosylated SARS-CoV-2 RBD Antigens Expressed in Glycoengineered Yeast Induce Strong Immune Responses Through High Antigen-Alum Adsorption.

Ai Li, Tiantian Wang, Bin Zhang, Xuchen Hou, Peng Sun, Hao Wang, Huifang Xu, Min Tan, Xin Gong, Jun Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ai LiDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Tiantian WangDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Bin ZhangDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Xuchen HouDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Peng SunDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Hao WangDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Huifang XuDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Min TanDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Xin GongDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Jun WuDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.
Bo LiuDepartment of Microorganism Engineering, Beijing Institute of Biotechnology, Beijing 100071, China.ORCID 0000-0001-6655-1866

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycosylation plays a pivotal role in regulating the functions and immunogenicity of antigens. Targeting the receptor-binding domain (RBD) of the spike protein (S protein) of SARS-CoV-2, we examined the impact of different glycoforms on RBD antigen immunogenicity and the underlying mechanisms. IgG-specific antibody titers and pseudovirus neutralization were compared in mice immunized with RBD antigens bearing different glycoforms, which were prepared using glycoengineering-capable

Indexed as

Antigens, ViralCOVID-19SARS-CoV-2Spike Glycoprotein, CoronavirusAdsorptionAlum CompoundsAluminum HydroxideAnimalsAntibodies, NeutralizingAntibodies, ViralFemaleGlycosylationHumansImmunoglobulin GMiceMice, Inbred BALB CAlum CompoundsAluminum Hydroxidealuminum sulfateAntibodies, NeutralizingAntibodies, ViralAntigens, ViralImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2aluminum hydroxide adjuvantCOVID-19 vaccinesglycoform modificationphosphomannose

Identifiers

PMID40867616
PMCPMC12384197

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.