Evidence map›Paper›PMID 40867892›Full record

ArticleAntioxidants (Basel, Switzerland)2025

The Mechanism of PMC (2,2,5,7,8-Pentamethyl-6-chromanol), a Sterically Hindered Phenol Antioxidant, in Rescuing Oxidized Low-Density-Lipoprotein-Induced Cytotoxicity in Human Retinal Pigment Epithelial Cells.

Suman Chaudhary, Jean Moon, Zhengping Hu, Emil Kriukov, Sergio Pestun, Petr Y Baranov, Yin-Shan Eric Ng, Patricia A D'Amore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suman ChaudharySchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Jean MoonSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Zhengping HuSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.ORCID 0000-0001-7369-1314
Emil KriukovSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.ORCID 0000-0001-8506-0448
Sergio PestunSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Petr Y BaranovSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Yin-Shan Eric NgSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Patricia A D'AmoreSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.

Funding

NEI NIH HHS P30EYE003790
6 · The paper itself

Abstract

Geographic atrophy or late-stage dry age-related macular degeneration (AMD) is characterized by drusen deposition and progressive retinal pigment epithelium (RPE) degeneration, leading to irreversible vision loss. The formation of drusen leads to dyshomeostasis, oxidative stress, and irreversible damage to the RPE. In this study, we used an in vitro model of oxidized low-density lipoprotein (ox-LDL)-induced human RPE damage/death to investigate the mechanism through which a sterically hindered phenol antioxidant compound, PMC (2,2,5,7,8-pentamethyl-6-chromanol), protects the RPE against ox-LDL-induced damage. We show that PMC exerts its protective effect by preventing the upregulation of stress-responsive heme oxygenase-1 (

Indexed as

antioxidantscytoprotectiongeographic atrophyoxidized low-density lipoproteinsretinal pigment epitheliumsterically hindered phenols

Identifiers

PMID40867892
PMCPMC12382756

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.